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Page 1
Metabolic barriers to cancer immunotherapy.
DePeaux K, Delgoffe GM. DePeaux K, et al. Nat Rev Immunol. 2021 Dec;21(12):785-797. doi: 10.1038/s41577-021-00541-y. Epub 2021 Apr 29. Nat Rev Immunol. 2021. PMID: 33927375 Free PMC article. Review.
CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours.
Zappasodi R, Serganova I, Cohen IJ, Maeda M, Shindo M, Senbabaoglu Y, Watson MJ, Leftin A, Maniyar R, Verma S, Lubin M, Ko M, Mane MM, Zhong H, Liu C, Ghosh A, Abu-Akeel M, Ackerstaff E, Koutcher JA, Ho PC, Delgoffe GM, Blasberg R, Wolchok JD, Merghoub T. Zappasodi R, et al. Nature. 2021 Mar;591(7851):652-658. doi: 10.1038/s41586-021-03326-4. Epub 2021 Feb 15. Nature. 2021. PMID: 33588426 Free PMC article.
Metabolic support of tumour-infiltrating regulatory T cells by lactic acid.
Watson MJ, Vignali PDA, Mullett SJ, Overacre-Delgoffe AE, Peralta RM, Grebinoski S, Menk AV, Rittenhouse NL, DePeaux K, Whetstone RD, Vignali DAA, Hand TW, Poholek AC, Morrison BM, Rothstein JD, Wendell SG, Delgoffe GM. Watson MJ, et al. Nature. 2021 Mar;591(7851):645-651. doi: 10.1038/s41586-020-03045-2. Epub 2021 Feb 15. Nature. 2021. PMID: 33589820 Free PMC article.
Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism.
Peralta RM, Xie B, Lontos K, Nieves-Rosado H, Spahr K, Joshi S, Ford BR, Quann K, Frisch AT, Dean V, Philbin M, Cillo AR, Gingras S, Poholek AC, Kane LP, Rivadeneira DB, Delgoffe GM. Peralta RM, et al. Nat Immunol. 2024 Dec;25(12):2297-2307. doi: 10.1038/s41590-024-01999-3. Epub 2024 Nov 8. Nat Immunol. 2024. PMID: 39516648 Free PMC article.
30 results