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Page 1
The beta agonist lung injury trial prevention. A randomized controlled trial.
Perkins GD, Gates S, Park D, Gao F, Knox C, Holloway B, McAuley DF, Ryan J, Marzouk J, Cooke MW, Lamb SE, Thickett DR; BALTI-Prevention Collaborators. Perkins GD, et al. Am J Respir Crit Care Med. 2014 Mar 15;189(6):674-83. doi: 10.1164/rccm.201308-1549OC. Am J Respir Crit Care Med. 2014. PMID: 24392848 Free PMC article. Clinical Trial.
Beta-Agonist Lung injury TrIal-2 (BALTI-2): a multicentre, randomised, double-blind, placebo-controlled trial and economic evaluation of intravenous infusion of salbutamol versus placebo in patients with acute respiratory distress syndrome.
Gates S, Perkins GD, Lamb SE, Kelly C, Thickett DR, Young JD, McAuley DF, Snaith C, McCabe C, Hulme CT, Gao Smith F. Gates S, et al. Health Technol Assess. 2013 Sep;17(38):v-vi, 1-87. doi: 10.3310/hta17380. Health Technol Assess. 2013. PMID: 24028755 Free PMC article. Clinical Trial.
Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS).
Dancer RC, Parekh D, Lax S, D'Souza V, Zheng S, Bassford CR, Park D, Bartis DG, Mahida R, Turner AM, Sapey E, Wei W, Naidu B, Stewart PM, Fraser WD, Christopher KB, Cooper MS, Gao F, Sansom DM, Martineau AR, Perkins GD, Thickett DR. Dancer RC, et al. Thorax. 2015 Jul;70(7):617-24. doi: 10.1136/thoraxjnl-2014-206680. Epub 2015 Apr 22. Thorax. 2015. PMID: 25903964 Free PMC article.
Exchange protein directly activated by cyclic AMP (EPAC) activation reverses neutrophil dysfunction induced by β2-agonists, corticosteroids, and critical illness.
Scott J, Harris GJ, Pinder EM, Macfarlane JG, Hellyer TP, Rostron AJ, Conway Morris A, Thickett DR, Perkins GD, McAuley DF, Widdrington JD, Wiscombe S, Baudouin SV, Roy AI, Linnett VC, Wright SE, Ruchaud-Sparagano MH, Simpson AJ. Scott J, et al. J Allergy Clin Immunol. 2016 Feb;137(2):535-44. doi: 10.1016/j.jaci.2015.07.036. Epub 2015 Sep 18. J Allergy Clin Immunol. 2016. PMID: 26388312 Free article.
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