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HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence.
Cui M, Yamano K, Yamamoto K, Yamamoto-Imoto H, Minami S, Yamamoto T, Matsui S, Kaminishi T, Shima T, Ogura M, Tsuchiya M, Nishino K, Layden BT, Kato H, Ogawa H, Oki S, Okada Y, Isaka Y, Kosako H, Matsuda N, Yoshimori T, Nakamura S. Cui M, et al. Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2306454120. doi: 10.1073/pnas.2306454120. Epub 2024 Jan 3. Proc Natl Acad Sci U S A. 2024. PMID: 38170752 Free PMC article.
Spatially-resolved transcriptomics reveal macrophage heterogeneity and prognostic significance in diffuse large B-cell lymphoma.
Liu M, Bertolazzi G, Sridhar S, Lee RX, Jaynes P, Mulder K, Syn N, Hoppe MM, Fan S, Peng Y, Thng J, Chua R, Jayalakshmi, Batumalai Y, De Mel S, Poon L, Chan EHL, Lee J, Hue SS, Chang ST, Chuang SS, Chandy KG, Ye X, Pan-Hammarström Q, Ginhoux F, Chee YL, Ng SB, Tripodo C, Jeyasekharan AD. Liu M, et al. Nat Commun. 2024 Mar 8;15(1):2113. doi: 10.1038/s41467-024-46220-z. Nat Commun. 2024. PMID: 38459052 Free PMC article.
Targeting senescent cells with NKG2D-CAR T cells.
Deng Y, Kumar A, Xie K, Schaaf K, Scifo E, Morsy S, Li T, Ehninger A, Bano D, Ehninger D. Deng Y, et al. Cell Death Discov. 2024 May 4;10(1):217. doi: 10.1038/s41420-024-01976-7. Cell Death Discov. 2024. PMID: 38704364 Free PMC article.
Atherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation.
Martinez-Campanario MC, Cortés M, Moreno-Lanceta A, Han L, Ninfali C, Domínguez V, Andrés-Manzano MJ, Farràs M, Esteve-Codina A, Enrich C, Díaz-Crespo FJ, Pintado B, Escolà-Gil JC, García de Frutos P, Andrés V, Melgar-Lesmes P, Postigo A. Martinez-Campanario MC, et al. Nat Commun. 2023 Dec 14;14(1):8316. doi: 10.1038/s41467-023-43896-7. Nat Commun. 2023. PMID: 38097578 Free PMC article.
404 results