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Page 1
Glycans are a novel biomarker of chronological and biological ages.
Krištić J, Vučković F, Menni C, Klarić L, Keser T, Beceheli I, Pučić-Baković M, Novokmet M, Mangino M, Thaqi K, Rudan P, Novokmet N, Sarac J, Missoni S, Kolčić I, Polašek O, Rudan I, Campbell H, Hayward C, Aulchenko Y, Valdes A, Wilson JF, Gornik O, Primorac D, Zoldoš V, Spector T, Lauc G. Krištić J, et al. J Gerontol A Biol Sci Med Sci. 2014 Jul;69(7):779-89. doi: 10.1093/gerona/glt190. Epub 2013 Dec 10. J Gerontol A Biol Sci Med Sci. 2014. PMID: 24325898 Free PMC article.
Glycomics meets lipidomics--associations of N-glycans with classical lipids, glycerophospholipids, and sphingolipids in three European populations.
Igl W, Polašek O, Gornik O, Knežević A, Pučić M, Novokmet M, Huffman J, Gnewuch C, Liebisch G, Rudd PM, Campbell H, Wilson JF, Rudan I, Gyllensten U, Schmitz G, Lauc G. Igl W, et al. Mol Biosyst. 2011 Jun;7(6):1852-62. doi: 10.1039/c0mb00095g. Epub 2011 Mar 28. Mol Biosyst. 2011. PMID: 21445428 Free article.
The association between galactosylation of immunoglobulin G and body mass index.
Nikolac Perkovic M, Pucic Bakovic M, Kristic J, Novokmet M, Huffman JE, Vitart V, Hayward C, Rudan I, Wilson JF, Campbell H, Polasek O, Lauc G, Pivac N. Nikolac Perkovic M, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jan 3;48:20-5. doi: 10.1016/j.pnpbp.2013.08.014. Epub 2013 Sep 5. Prog Neuropsychopharmacol Biol Psychiatry. 2014. PMID: 24012618
Association of medication with the human plasma N-glycome.
Saldova R, Huffman JE, Adamczyk B, Mužinić A, Kattla JJ, Pučić M, Novokmet M, Abrahams JL, Hayward C, Rudan I, Wild SH, Wright AF, Polašek O, Lauc G, Campbell H, Wilson JF, Rudd PM. Saldova R, et al. J Proteome Res. 2012 Mar 2;11(3):1821-31. doi: 10.1021/pr2010605. Epub 2012 Feb 9. J Proteome Res. 2012. PMID: 22256781
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
Lauc G, Essafi A, Huffman JE, Hayward C, Knežević A, Kattla JJ, Polašek O, Gornik O, Vitart V, Abrahams JL, Pučić M, Novokmet M, Redžić I, Campbell S, Wild SH, Borovečki F, Wang W, Kolčić I, Zgaga L, Gyllensten U, Wilson JF, Wright AF, Hastie ND, Campbell H, Rudd PM, Rudan I. Lauc G, et al. PLoS Genet. 2010 Dec 23;6(12):e1001256. doi: 10.1371/journal.pgen.1001256. PLoS Genet. 2010. PMID: 21203500 Free PMC article.
Polymorphisms in B3GAT1, SLC9A9 and MGAT5 are associated with variation within the human plasma N-glycome of 3533 European adults.
Huffman JE, Knezevic A, Vitart V, Kattla J, Adamczyk B, Novokmet M, Igl W, Pucic M, Zgaga L, Johannson Å, Redzic I, Gornik O, Zemunik T, Polasek O, Kolcic I, Pehlic M, Koeleman CA, Campbell S, Wild SH, Hastie ND, Campbell H, Gyllensten U, Wuhrer M, Wilson JF, Hayward C, Rudan I, Rudd PM, Wright AF, Lauc G. Huffman JE, et al. Hum Mol Genet. 2011 Dec 15;20(24):5000-11. doi: 10.1093/hmg/ddr414. Epub 2011 Sep 9. Hum Mol Genet. 2011. PMID: 21908519
Mutations in HNF1A result in marked alterations of plasma glycan profile.
Thanabalasingham G, Huffman JE, Kattla JJ, Novokmet M, Rudan I, Gloyn AL, Hayward C, Adamczyk B, Reynolds RM, Muzinic A, Hassanali N, Pucic M, Bennett AJ, Essafi A, Polasek O, Mughal SA, Redzic I, Primorac D, Zgaga L, Kolcic I, Hansen T, Gasperikova D, Tjora E, Strachan MW, Nielsen T, Stanik J, Klimes I, Pedersen OB, Njølstad PR, Wild SH, Gyllensten U, Gornik O, Wilson JF, Hastie ND, Campbell H, McCarthy MI, Rudd PM, Owen KR, Lauc G, Wright AF. Thanabalasingham G, et al. Diabetes. 2013 Apr;62(4):1329-37. doi: 10.2337/db12-0880. Epub 2012 Dec 28. Diabetes. 2013. PMID: 23274891 Free PMC article.
High throughput isolation and glycosylation analysis of IgG-variability and heritability of the IgG glycome in three isolated human populations.
Pucić M, Knezević A, Vidic J, Adamczyk B, Novokmet M, Polasek O, Gornik O, Supraha-Goreta S, Wormald MR, Redzić I, Campbell H, Wright A, Hastie ND, Wilson JF, Rudan I, Wuhrer M, Rudd PM, Josić D, Lauc G. Pucić M, et al. Mol Cell Proteomics. 2011 Oct;10(10):M111.010090. doi: 10.1074/mcp.M111.010090. Epub 2011 Jun 8. Mol Cell Proteomics. 2011. PMID: 21653738 Free PMC article.
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Lauc G, Huffman JE, Pučić M, Zgaga L, Adamczyk B, Mužinić A, Novokmet M, Polašek O, Gornik O, Krištić J, Keser T, Vitart V, Scheijen B, Uh HW, Molokhia M, Patrick AL, McKeigue P, Kolčić I, Lukić IK, Swann O, van Leeuwen FN, Ruhaak LR, Houwing-Duistermaat JJ, Slagboom PE, Beekman M, de Craen AJ, Deelder AM, Zeng Q, Wang W, Hastie ND, Gyllensten U, Wilson JF, Wuhrer M, Wright AF, Rudd PM, Hayward C, Aulchenko Y, Campbell H, Rudan I. Lauc G, et al. PLoS Genet. 2013;9(1):e1003225. doi: 10.1371/journal.pgen.1003225. Epub 2013 Jan 31. PLoS Genet. 2013. PMID: 23382691 Free PMC article.
Does inbreeding affect N-glycosylation of human plasma proteins?
Polašek O, Leutenegger AL, Gornik O, Zgaga L, Kolcic I, McQuillan R, Wilson JF, Hayward C, Wright AF, Lauc G, Campbell H, Rudan I. Polašek O, et al. Mol Genet Genomics. 2011 May;285(5):427-32. doi: 10.1007/s00438-011-0620-5. Epub 2011 Apr 13. Mol Genet Genomics. 2011. PMID: 21487732