CA135405/CA/NCI NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2010	1
2011	4
2012	2
2013	2
2015	1
2016	4
2017	2
2018	1
2019	1
2021	1
2023	1
2024	1
2025	0

1

Combined inhibition of MTAP and MAT2a mimics synthetic lethality in tumor models via PRMT5 inhibition.

Bedard GT, Gilaj N, Peregrina K, Brew I, Tosti E, Shaffer K, Tyler PC, Edelmann W, Augenlicht LH, Schramm VL. Bedard GT, et al. J Biol Chem. 2024 Jan;300(1):105492. doi: 10.1016/j.jbc.2023.105492. Epub 2023 Nov 23. J Biol Chem. 2024. PMID: 38000655 Free PMC article.

2

Enzymatic Transition States and Drug Design.

Schramm VL. Schramm VL. Chem Rev. 2018 Nov 28;118(22):11194-11258. doi: 10.1021/acs.chemrev.8b00369. Epub 2018 Oct 18. Chem Rev. 2018. PMID: 30335982 Free PMC article. Review.

3

Human DNMT1 transition state structure.

Du Q, Wang Z, Schramm VL. Du Q, et al. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):2916-21. doi: 10.1073/pnas.1522491113. Epub 2016 Feb 29. Proc Natl Acad Sci U S A. 2016. PMID: 26929335 Free PMC article.

4

Enzymatic transition states, transition-state analogs, dynamics, thermodynamics, and lifetimes.

Schramm VL. Schramm VL. Annu Rev Biochem. 2011;80:703-32. doi: 10.1146/annurev-biochem-061809-100742. Annu Rev Biochem. 2011. PMID: 21675920 Free PMC article. Review.

5

Transition States, analogues, and drug development.

Schramm VL. Schramm VL. ACS Chem Biol. 2013 Jan 18;8(1):71-81. doi: 10.1021/cb300631k. Epub 2013 Jan 4. ACS Chem Biol. 2013. PMID: 23259601 Free PMC article. Review.

6

Continuous Fluorescence Assays for Reactions Involving Adenine.

Firestone RS, Cameron SA, Tyler PC, Ducati RG, Spitz AZ, Schramm VL. Firestone RS, et al. Anal Chem. 2016 Dec 6;88(23):11860-11867. doi: 10.1021/acs.analchem.6b03621. Epub 2016 Nov 11. Anal Chem. 2016. PMID: 27779859 Free PMC article.

7

Transition state analogue of MTAP extends lifespan of APC^Min/+ mice.

Firestone RS, Feng M, Basu I, Peregrina K, Augenlicht LH, Schramm VL. Firestone RS, et al. Sci Rep. 2021 Apr 23;11(1):8844. doi: 10.1038/s41598-021-87734-6. Sci Rep. 2021. PMID: 33893330 Free PMC article.

8

Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36.

Poulin MB, Schneck JL, Matico RE, McDevitt PJ, Huddleston MJ, Hou W, Johnson NW, Thrall SH, Meek TD, Schramm VL. Poulin MB, et al. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1197-201. doi: 10.1073/pnas.1521036113. Epub 2016 Jan 19. Proc Natl Acad Sci U S A. 2016. PMID: 26787850 Free PMC article.

9

Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase.

Harijan RK, Hoff O, Ducati RG, Firestone RS, Hirsch BM, Evans GB, Schramm VL, Tyler PC. Harijan RK, et al. J Med Chem. 2019 Apr 11;62(7):3286-3296. doi: 10.1021/acs.jmedchem.8b01642. Epub 2019 Mar 28. J Med Chem. 2019. PMID: 30860833 Free PMC article.

10

Chemoenzymatic Synthesis of (36)S Isotopologues of Methionine and S-Adenosyl-L-methionine.

Poulin MB, Du Q, Schramm VL. Poulin MB, et al. J Org Chem. 2015 May 15;80(10):5344-7. doi: 10.1021/acs.joc.5b00608. Epub 2015 Apr 23. J Org Chem. 2015. PMID: 25884979

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