CA023108-31S4/CA/NCI NIH HHS/United States[Grants and Funding] - Search Results

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The putative BH3 mimetic S1 sensitizes leukemia to ABT-737 by increasing reactive oxygen species, inducing endoplasmic reticulum stress, and upregulating the BH3-only protein NOXA.

Soderquist R, Pletnev AA, Danilov AV, Eastman A. Soderquist R, et al. Apoptosis. 2014 Jan;19(1):201-9. doi: 10.1007/s10495-013-0910-y. Apoptosis. 2014. PMID: 24072590 Free PMC article.

Gossypol increases expression of the pro-apoptotic BH3-only protein NOXA through a novel mechanism involving phospholipase A2, cytoplasmic calcium, and endoplasmic reticulum stress.

Soderquist RS, Danilov AV, Eastman A. Soderquist RS, et al. J Biol Chem. 2014 Jun 6;289(23):16190-9. doi: 10.1074/jbc.M114.562900. Epub 2014 Apr 28. J Biol Chem. 2014. PMID: 24778183 Free PMC article.

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