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Intestinal epithelial-specific PTEN inactivation results in tumor formation.
Byun DS, Ahmed N, Nasser S, Shin J, Al-Obaidi S, Goel S, Corner GA, Wilson AJ, Flanagan DJ, Williams DS, Augenlicht LH, Vincan E, Mariadason JM. Byun DS, et al. Am J Physiol Gastrointest Liver Physiol. 2011 Nov;301(5):G856-64. doi: 10.1152/ajpgi.00178.2011. Epub 2011 Aug 11. Am J Physiol Gastrointest Liver Physiol. 2011. PMID: 21836055 Free PMC article.
HDAC4 promotes growth of colon cancer cells via repression of p21.
Wilson AJ, Byun DS, Nasser S, Murray LB, Ayyanar K, Arango D, Figueroa M, Melnick A, Kao GD, Augenlicht LH, Mariadason JM. Wilson AJ, et al. Mol Biol Cell. 2008 Oct;19(10):4062-75. doi: 10.1091/mbc.e08-02-0139. Epub 2008 Jul 16. Mol Biol Cell. 2008. PMID: 18632985 Free PMC article.