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Page 1
DNA-PKcs-mediated transcriptional regulation of TOP2B drives chemoresistance in acute myeloid leukemia.
Mishra SV, Banerjee A, Sarkar D, Thangarathnam V, Bagal B, Hasan SK, Dutt S. Mishra SV, et al. J Cell Sci. 2024 Feb 1;137(3):jcs261931. doi: 10.1242/jcs.261931. Epub 2024 Feb 13. J Cell Sci. 2024. PMID: 38240344
Anthracyclines, topoisomerase II enzyme poisons that cause DNA damage, are the mainstay of acute myeloid leukemia (AML) treatment. However, acquired resistance to anthracyclines leads to relapse, which currently lacks effective treatment and is the cause of poor sur …
Anthracyclines, topoisomerase II enzyme poisons that cause DNA damage, are the mainstay of acute myeloid leukemia (AML) treatment. Ho …
Epithelial-to-mesenchymal transition status correlated with ultrastructural features, and TP53 mutation in patient-derived oral cancer cell lines.
Navarange SS, Bane SM, Mehta D, Shah S, Gupta S, Waghmare SK. Navarange SS, et al. Mol Biol Rep. 2023 Oct;50(10):8469-8481. doi: 10.1007/s11033-023-08720-x. Epub 2023 Aug 28. Mol Biol Rep. 2023. PMID: 37639153
Additionally, TP53, an important tumor suppressor gene, is also a significant determinant of the treatment outcome, and also plays a role in EMT. Therefore, understanding the interconnections between ultrastructural features, EMT status and TP53 mutational status is of vit …
Additionally, TP53, an important tumor suppressor gene, is also a significant determinant of the treatment outcome, and also plays a …
Concomitant overexpression of Activin A and p63 is associated with poor outcome in oral cancer patients.
Mundhe D, Waghole R, Pawar S, Mishra R, Shetty A, Gera P, Kannan S, Teni T. Mundhe D, et al. J Oral Pathol Med. 2020 Oct;49(9):876-885. doi: 10.1111/jop.13049. Epub 2020 Jun 28. J Oral Pathol Med. 2020. PMID: 32512627
Activin betaA overexpression was associated with advanced tumor stage (P = .021), positive nodes (P = .045), poor recurrence-free survival (P = .013), and overall survival (P = .024), while its concomitant overexpression with p63 was a better predictor of recurrence-free s …
Activin betaA overexpression was associated with advanced tumor stage (P = .021), positive nodes (P = .045), poor recurrence-free sur …
Prognostic and predictive significance of nuclear HIF1alpha expression in locally advanced HNSCC patients treated with chemoradiation with or without nimotuzumab.
Patel U, Pandey M, Kannan S, Samant TA, Gera P, Mittal N, Rane S, Patil A, Noronha V, Joshi A, Patil VM, Prabhash K, Mahimkar MB. Patel U, et al. Br J Cancer. 2020 Dec;123(12):1757-1766. doi: 10.1038/s41416-020-01064-4. Epub 2020 Sep 17. Br J Cancer. 2020. PMID: 32939054 Free PMC article. Clinical Trial.
Here, we present the prognostic and predictive association of biomarkers in HPV-negative locally advanced (LA) HNSCC patients. METHODS: Treatment-naive tumour tissue samples of 404 patients, a subset of randomised Phase 3 trial comparing cisplatin radiation (CRT) ve …
Here, we present the prognostic and predictive association of biomarkers in HPV-negative locally advanced (LA) HNSCC patients. METHOD …
Comprehensive immune cell profiling depicts an early immune response associated with severe coronavirus disease 2019 in cancer patients.
Tembhare PR, Sriram H, Chatterjee G, Khanka T, Gokarn A, Mirgh S, Rajendra A, Chaturvedi A, Ghogale SG, Deshpande N, Girase K, Dalvi K, Rajpal S, Patkar N, Trivedi B, Joshi A, Murthy V, Shetty N, Nair S, More A, Kamtalwar S, Chavan P, Bhat V, Bhat P, Subramanian PG, Gupta S, Khattry N. Tembhare PR, et al. Immunol Cell Biol. 2022 Jan;100(1):61-73. doi: 10.1111/imcb.12504. Epub 2021 Oct 27. Immunol Cell Biol. 2022. PMID: 34582592 Free PMC article.
Biphasic DNA damage and non-canonical replication stress response govern radiation-induced senescence in glioblastoma.
Ghorai A, Singh B, Dutt S. Ghorai A, et al. J Cell Sci. 2024 Dec 15;137(24):jcs261844. doi: 10.1242/jcs.261844. Epub 2024 Dec 19. J Cell Sci. 2024. PMID: 39568404
Therapy-induced senescence (TIS) in glioblastoma (GBM) residual disease and escape from TIS account for resistance and recurrence, but the mechanism of TIS manifestation remains obscure. Here, we demonstrate that replication stress (RS) is critical for the induction of TIS …
Therapy-induced senescence (TIS) in glioblastoma (GBM) residual disease and escape from TIS account for resistance and recurrence, bu …