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Cdk5 is a key factor in tau aggregation and tangle formation in vivo.
Noble W, Olm V, Takata K, Casey E, Mary O, Meyerson J, Gaynor K, LaFrancois J, Wang L, Kondo T, Davies P, Burns M, Veeranna, Nixon R, Dickson D, Matsuoka Y, Ahlijanian M, Lau LF, Duff K. Noble W, et al. Neuron. 2003 May 22;38(4):555-65. doi: 10.1016/s0896-6273(03)00259-9. Neuron. 2003. PMID: 12765608 Free article.