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Page 1
Pharmacological targeting of netrin-1 inhibits EMT in cancer.
Lengrand J, Pastushenko I, Vanuytven S, Song Y, Venet D, Sarate RM, Bellina M, Moers V, Boinet A, Sifrim A, Rama N, Ducarouge B, Van Herck J, Dubois C, Scozzaro S, Lemaire S, Gieskes S, Bonni S, Collin A, Braissand N, Allard J, Zindy E, Decaestecker C, Sotiriou C, Salmon I, Mehlen P, Voet T, Bernet A, Blanpain C. Lengrand J, et al. Nature. 2023 Aug;620(7973):402-408. doi: 10.1038/s41586-023-06372-2. Epub 2023 Aug 2. Nature. 2023. PMID: 37532929 Free PMC article.
Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis.
Pastushenko I, Mauri F, Song Y, de Cock F, Meeusen B, Swedlund B, Impens F, Van Haver D, Opitz M, Thery M, Bareche Y, Lapouge G, Vermeersch M, Van Eycke YR, Balsat C, Decaestecker C, Sokolow Y, Hassid S, Perez-Bustillo A, Agreda-Moreno B, Rios-Buceta L, Jaen P, Redondo P, Sieira-Gil R, Millan-Cayetano JF, Sanmatrtin O, D'Haene N, Moers V, Rozzi M, Blondeau J, Lemaire S, Scozzaro S, Janssens V, De Troya M, Dubois C, Pérez-Morga D, Salmon I, Sotiriou C, Helmbacher F, Blanpain C. Pastushenko I, et al. Nature. 2021 Jan;589(7842):448-455. doi: 10.1038/s41586-020-03046-1. Epub 2020 Dec 16. Nature. 2021. PMID: 33328637 Free PMC article.
The extracellular matrix dictates regional competence for tumour initiation.
Bansaccal N, Vieugue P, Sarate R, Song Y, Minguijon E, Miroshnikova YA, Zeuschner D, Collin A, Allard J, Engelman D, Delaunois AL, Liagre M, de Groote L, Timmerman E, Van Haver D, Impens F, Salmon I, Wickström SA, Sifrim A, Blanpain C. Bansaccal N, et al. Nature. 2023 Nov;623(7988):828-835. doi: 10.1038/s41586-023-06740-y. Epub 2023 Nov 15. Nature. 2023. PMID: 37968399 Free PMC article.
Mesp1 controls the chromatin and enhancer landscapes essential for spatiotemporal patterning of early cardiovascular progenitors.
Lin X, Swedlund B, Ton MN, Ghazanfar S, Guibentif C, Paulissen C, Baudelet E, Plaindoux E, Achouri Y, Calonne E, Dubois C, Mansfield W, Zaffran S, Marioni JC, Fuks F, Göttgens B, Lescroart F, Blanpain C. Lin X, et al. Nat Cell Biol. 2022 Jul;24(7):1114-1128. doi: 10.1038/s41556-022-00947-3. Epub 2022 Jul 11. Nat Cell Biol. 2022. PMID: 35817961 Free PMC article.
Modeling the complexity of mammary gland in vitro.
Fioramonti M, Blanpain C. Fioramonti M, et al. Nat Methods. 2023 Dec;20(12):1879-1880. doi: 10.1038/s41592-023-02064-x. Nat Methods. 2023. PMID: 37919420 Free PMC article. No abstract available.
NR2F2 controls malignant squamous cell carcinoma state by promoting stemness and invasion and repressing differentiation.
Mauri F, Schepkens C, Lapouge G, Drogat B, Song Y, Pastushenko I, Rorive S, Blondeau J, Golstein S, Bareche Y, Miglianico M, Nkusi E, Rozzi M, Moers V, Brisebarre A, Raphaël M, Dubois C, Allard J, Durdu B, Ribeiro F, Sotiriou C, Salmon I, Vakili J, Blanpain C. Mauri F, et al. Nat Cancer. 2021 Nov;2(11):1152-1169. doi: 10.1038/s43018-021-00287-5. Epub 2021 Nov 22. Nat Cancer. 2021. PMID: 35122061 Free PMC article.
Survivin promotes stem cell competence for skin cancer initiation.
Canato S, Sarate R, Carvalho-Marques S, Maia Soares R, Song Y, Monteiro-Ferreira S, Vieugué P, Liagre M, Grossi G, Cardoso E, Dubois C, Conway EM, Schenone S, Sanchez-Danes A, Blanpain C. Canato S, et al. Cancer Discov. 2024 Nov 11:10.1158/2159-8290.CD-24-0263. doi: 10.1158/2159-8290.CD-24-0263. Online ahead of print. Cancer Discov. 2024. PMID: 39526566