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The sterol-sensing domain (SSD) directly mediates signal-regulated endoplasmic reticulum-associated degradation (ERAD) of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase isozyme Hmg2.
J Biol Chem. 2011 Jul 29;286(30):26298-307. doi: 10.1074/jbc.M111.244798. Epub 2011 May 31.
J Biol Chem. 2011.
PMID: 21628456
Free PMC article.
Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast.
Theesfeld CL, Hampton RY.
Theesfeld CL, et al.
J Biol Chem. 2013 Mar 22;288(12):8519-8530. doi: 10.1074/jbc.M112.404517. Epub 2013 Jan 10.
J Biol Chem. 2013.
PMID: 23306196
Free PMC article.
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