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Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine.
Kavanagh ME, Horning BD, Khattri R, Roy N, Lu JP, Whitby LR, Ye E, Brannon JC, Parker A, Chick JM, Eissler CL, Wong AJ, Rodriguez JL, Rodiles S, Masuda K, Teijaro JR, Simon GM, Patricelli MP, Cravatt BF. Kavanagh ME, et al. Nat Chem Biol. 2022 Dec;18(12):1388-1398. doi: 10.1038/s41589-022-01098-0. Epub 2022 Sep 12. Nat Chem Biol. 2022. PMID: 36097295 Free PMC article.
Glutathione supports lipid abundance in vivo.
Asantewaa G, Tuttle ET, Ward NP, Kang YP, Kim Y, Kavanagh ME, Girnius N, Chen Y, Duncan R, Rodriguez K, Hecht F, Zocchi M, Smorodintsev-Schiller L, Scales TQ, Taylor K, Alimohammadi F, Sechrist ZR, Agostini-Vulaj D, Schafer XL, Chang H, Smith Z, O'Connor TN, Whelan S, Selfors LM, Crowdis J, Gray GK, Bronson RT, Brenner D, Rufini A, Dirksen RT, Hezel AF, Huber AR, Munger J, Cravatt BF, Vasiliou V, Cole CL, DeNicola GM, Harris IS. Asantewaa G, et al. bioRxiv [Preprint]. 2023 Feb 11:2023.02.10.524960. doi: 10.1101/2023.02.10.524960. bioRxiv. 2023. Update in: Nat Commun. 2024 Jul 21;15(1):6152. doi: 10.1038/s41467-024-50454-2 PMID: 36798186 Free PMC article. Updated. Preprint.
A proteome-wide atlas of lysine-reactive chemistry.
Abbasov ME, Kavanagh ME, Ichu TA, Lazear MR, Tao Y, Crowley VM, Am Ende CW, Hacker SM, Ho J, Dix MM, Suciu R, Hayward MM, Kiessling LL, Cravatt BF. Abbasov ME, et al. Nat Chem. 2021 Nov;13(11):1081-1092. doi: 10.1038/s41557-021-00765-4. Epub 2021 Sep 9. Nat Chem. 2021. PMID: 34504315 Free PMC article.