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Page 1
Target-induced clustering activates Trim-Away of pathogens and proteins.
Zeng J, Santos AF, Mukadam AS, Osswald M, Jacques DA, Dickson CF, McLaughlin SH, Johnson CM, Kiss L, Luptak J, Renner N, Vaysburd M, McEwan WA, Morais-de-Sá E, Clift D, James LC. Zeng J, et al. Nat Struct Mol Biol. 2021 Mar;28(3):278-289. doi: 10.1038/s41594-021-00560-2. Epub 2021 Feb 25. Nat Struct Mol Biol. 2021. PMID: 33633400 Free PMC article.
Antibodies in the intracellular domain.
McEwan WA. McEwan WA. Semin Cell Dev Biol. 2022 Jun;126:97-98. doi: 10.1016/j.semcdb.2022.02.020. Epub 2022 Feb 28. Semin Cell Dev Biol. 2022. PMID: 35241366 Free PMC article. No abstract available.
Cholesterol determines the cytosolic entry and seeded aggregation of tau.
Tuck BJ, Miller LVC, Katsinelos T, Smith AE, Wilson EL, Keeling S, Cheng S, Vaysburd MJ, Knox C, Tredgett L, Metzakopian E, James LC, McEwan WA. Tuck BJ, et al. Cell Rep. 2022 May 3;39(5):110776. doi: 10.1016/j.celrep.2022.110776. Cell Rep. 2022. PMID: 35508140 Free PMC article.
Tau seeds from Alzheimer's disease brains trigger tau spread in macaques while oligomeric-Aβ mediates pathology maturation.
Darricau M, Dou C, Kinet R, Zhu T, Zhou L, Li X, Bedel A, Claverol S, Tokarski C, Katsinelos T, McEwan WA, Zhang L, Gao R, Bourdenx M, Dehay B, Qin C, Bezard E, Planche V. Darricau M, et al. Alzheimers Dement. 2024 Mar;20(3):1894-1912. doi: 10.1002/alz.13604. Epub 2023 Dec 26. Alzheimers Dement. 2024. PMID: 38148705 Free PMC article.
15 results