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Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes.
Sparbier CE, Gillespie A, Gomez J, Kumari N, Motazedian A, Chan KL, Bell CC, Gilan O, Chan YC, Popp S, Gough DJ, Eckersley-Maslin MA, Dawson SJ, Lehner PJ, Sutherland KD, Ernst P, McGeehan GM, Lam EYN, Burr ML, Dawson MA. Sparbier CE, et al. Nat Cell Biol. 2023 Feb;25(2):258-272. doi: 10.1038/s41556-022-01056-x. Epub 2023 Jan 12. Nat Cell Biol. 2023. PMID: 36635503 Free PMC article.
Staggered starts in the race to T cell activation.
Richard AC, Frazer GL, Ma CY, Griffiths GM. Richard AC, et al. Trends Immunol. 2021 Nov;42(11):994-1008. doi: 10.1016/j.it.2021.09.004. Epub 2021 Oct 11. Trends Immunol. 2021. PMID: 34649777 Free PMC article. Review.