Metastasis-enhancing protein KITENIN confers temozolomide resistance on glioblastoma with unmethylated MGMT via upregulation of cancer stem cell makers

Clin Transl Med. 2024 Aug;14(8):e1804. doi: 10.1002/ctm2.1804.

Authors

Eun-Jung Ahn^{1

2}, Yeong Jin Kim¹, Md Rashedunnabi Akanda², Se-Jeong Oh^{1

2}, Tae-Young Jung¹, Shin Jung¹, Jae-Hyuk Lee², Sung Sun Kim², Yong Yeon Jeong³, Hyung-Ho Ha⁴, Hoon Hyun⁵, Hangun Kim⁴, Joon Haeng Rhee⁶, Kyung Keun Kim⁷, Kyung-Hwa Lee^{2

8}, Kyung-Sub Moon¹

Affiliations

¹ Department of Neurosurgery, Chonnam National University Hwasun Hospital and Medical School, Hwasun, South Korea.
² Department of Pathology, Chonnam National University Hwasun Hospital and Medical School, Hwasun, South Korea.
³ Department of Radiology, Chonnam National University Hwasun Hospital and Medical School, Hwasun, South Korea.
⁴ College of Pharmacy, Sunchon National University, Sunchon, South Korea.
⁵ Department of Biomedical Sciences, Chonnam National University Medical School, Hwasun, South Korea.
⁶ Medical Research Center (MRC) for Immunotherapy of Cancer, Chonnam National University Medical School, Hwasun, South Korea.
⁷ Department of Pharmacology, Chonnam National University Medical School, Hwasun, South Korea.
⁸ BioMedical Sciences Graduate Program (BMSGP), Chonnam National University, Hwasun, South Korea.

No abstract available

Publication types

Letter

MeSH terms

Antineoplastic Agents, Alkylating / pharmacology
Antineoplastic Agents, Alkylating / therapeutic use
DNA Modification Methylases* / genetics
DNA Modification Methylases* / metabolism
DNA Repair Enzymes* / genetics
DNA Repair Enzymes* / metabolism
Drug Resistance, Neoplasm* / drug effects
Drug Resistance, Neoplasm* / genetics
Glioblastoma* / drug therapy
Glioblastoma* / genetics
Glioblastoma* / metabolism
Glioblastoma* / pathology
Humans
Neoplastic Stem Cells* / drug effects
Neoplastic Stem Cells* / metabolism
Temozolomide* / pharmacology
Temozolomide* / therapeutic use
Tumor Suppressor Proteins / genetics
Tumor Suppressor Proteins / metabolism
Up-Regulation* / drug effects

Substances

Temozolomide
MGMT protein, human
DNA Modification Methylases
DNA Repair Enzymes
Tumor Suppressor Proteins
Antineoplastic Agents, Alkylating

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