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Adenylyl cyclase increases survival in cardiomyopathy.
Roth DM, Bayat H, Drumm JD, Gao MH, Swaney JS, Ander A, Hammond HK. Roth DM, et al. Circulation. 2002 Apr 23;105(16):1989-94. doi: 10.1161/01.cir.0000014968.54967.d3. Circulation. 2002. PMID: 11997288
Concurrent expression of AC reduced end-diastolic diameter (Gq, 4.20+/-0.15 mm, n=12; Gq/AC, 3.68+/-0.12 mm, n=7; P<0.05) and increased fractional shortening (Gq, 32+/-1%, n=12; Gq/AC, 41+/-2%, n=7; P<0.001). Cardiac myocytes from Gq/AC mice showed increased forskoli …
Concurrent expression of AC reduced end-diastolic diameter (Gq, 4.20+/-0.15 mm, n=12; Gq/AC, 3.68+/-0.12 mm, n=7; P<0.05) and increased f …
Controlled expression of cardiac-directed adenylylcyclase type VI provides increased contractile function.
Gao MH, Bayat H, Roth DM, Yao Zhou J, Drumm J, Burhan J, Hammond HK. Gao MH, et al. Cardiovasc Res. 2002 Nov;56(2):197-204. doi: 10.1016/s0008-6363(02)00539-4. Cardiovasc Res. 2002. PMID: 12393090
The estimated half-life of newly synthesized cardiac AC(VI) protein was 2-3 days. Isolated cardiac myocytes from animals that had tet-suppression removed for 10 days showed increased cAMP production in response to forskolin stimulation (Transgene Off: 15+/-6 fmol/microg; T …
The estimated half-life of newly synthesized cardiac AC(VI) protein was 2-3 days. Isolated cardiac myocytes from animals that had tet …