Abstract
Antimicrobial therapies for oral diseases have been in use for centuries, but have undergone rapid changes in the last decade. In the coming years, antimicrobial strategies will become more sophisticated and efficacy will be greatly improved as new therapeutic technologies emerge. New delivery systems for common antimicrobials and novel agents to modulate the immune system, as well as biofilm formation and maturation, may be on the horizon. This review describes the development and the application of intraoral antimicrobial drug delivery in the oral environment. Current clinical uses of antimicrobials as well as future approaches to the treatment and prevention of oral infectious diseases are discussed.
Copyright 2005 Prous Science. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Administration, Oral
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Anti-Infective Agents / administration & dosage*
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Anti-Infective Agents, Local / administration & dosage
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Biofilms / drug effects
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Clinical Trials as Topic
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Defensins / administration & dosage
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Defensins / therapeutic use
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Dental Plaque / drug therapy*
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Dental Plaque / microbiology
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Drug Carriers
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Drug Delivery Systems / methods
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Drug Delivery Systems / trends*
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Gingivitis / drug therapy
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Gingivitis / microbiology
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Histidine-Rich Glycoprotein
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Humans
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Peptides, Cyclic / administration & dosage
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Peptides, Cyclic / therapeutic use
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Periodontitis / drug therapy*
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Periodontitis / microbiology
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Periodontitis / prevention & control
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Proteins / administration & dosage
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Proteins / therapeutic use
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Stomatitis, Denture / drug therapy*
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Stomatitis, Denture / microbiology
Substances
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Anti-Infective Agents
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Anti-Infective Agents, Local
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Defensins
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Drug Carriers
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Peptides, Cyclic
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Proteins
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Histidine-Rich Glycoprotein
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bactenecin