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Hypoxia-inducible factor-2α directly promotes BCRP expression and mediates the resistance of ovarian cancer stem cells to adriamycin.
He M, Wu H, Jiang Q, Liu Y, Han L, Yan Y, Wei B, Liu F, Deng X, Chen H, Zhao L, Wang M, Wu X, Yao W, Zhao H, Chen J, Wei M. He M, et al. Mol Oncol. 2019 Feb;13(2):403-421. doi: 10.1002/1878-0261.12419. Epub 2019 Jan 14. Mol Oncol. 2019. PMID: 30536571 Free PMC article.
OVCAR-3 and CAOV-3 sphere-forming (OVCAR-3 S and CAOV-3 S) cells with OCSC-like properties showed strong resistance to adriamycin (ADR). ...Knockdown of HIF-2alpha expression substantially attenuated the resistance of OVCAR-3 S and CAOV-3 S cells to AD …
OVCAR-3 and CAOV-3 sphere-forming (OVCAR-3 S and CAOV-3 S) cells with OCSC-like properties showed strong resistance to adriamy …