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Page 1
TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells.
Woznicki JA, Saini N, Flood P, Rajaram S, Lee CM, Stamou P, Skowyra A, Bustamante-Garrido M, Regazzoni K, Crawford N, McDade SS, Longley DB, Aza-Blanc P, Shanahan F, Zulquernain SA, McCarthy J, Melgar S, McRae BL, Nally K. Woznicki JA, et al. Cell Death Dis. 2021 Sep 23;12(10):864. doi: 10.1038/s41419-021-04151-3. Cell Death Dis. 2021. PMID: 34556638 Free PMC article.
Therapeutics Targeting the Core Apoptotic Machinery.
Hamilton C, Fox JP, Longley DB, Higgins CA. Hamilton C, et al. Cancers (Basel). 2021 May 26;13(11):2618. doi: 10.3390/cancers13112618. Cancers (Basel). 2021. PMID: 34073507 Free PMC article. Review.
Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features.
Flanagan DJ, Amirkhah R, Vincent DF, Gunduz N, Gentaz P, Cammareri P, McCooey AJ, McCorry AMB, Fisher NC, Davis HL, Ridgway RA, Lohuis J, Leach JDG, Jackstadt R, Gilroy K, Mariella E, Nixon C, Clark W, Hedley A, Markert EK, Strathdee D, Bartholin L, Redmond KL, Kerr EM, Longley DB, Ginty F, Cho S, Coleman HG, Loughrey MB, Bardelli A, Maughan TS, Campbell AD, Lawler M, Leedham SJ, Barry ST, Inman GJ, van Rheenen J, Dunne PD, Sansom OJ. Flanagan DJ, et al. Nat Commun. 2022 Dec 7;13(1):7551. doi: 10.1038/s41467-022-35134-3. Nat Commun. 2022. PMID: 36477656 Free PMC article.
The role of Ubiquitination in Apoptosis and Necroptosis.
Roberts JZ, Crawford N, Longley DB. Roberts JZ, et al. Cell Death Differ. 2022 Feb;29(2):272-284. doi: 10.1038/s41418-021-00922-9. Epub 2021 Dec 15. Cell Death Differ. 2022. PMID: 34912054 Free PMC article. Review.
Clinical Positioning of the IAP Antagonist Tolinapant (ASTX660) in Colorectal Cancer.
Crawford N, Stott KJ, Sessler T, McCann C, McDaid W, Lees A, Latimer C, Fox JP, Munck JM, Smyth T, Shah A, Martins V, Lawler M, Dunne PD, Kerr EM, McDade SS, Coyle VM, Longley DB. Crawford N, et al. Mol Cancer Ther. 2021 Sep;20(9):1627-1639. doi: 10.1158/1535-7163.MCT-20-1050. Epub 2021 Aug 13. Mol Cancer Ther. 2021. PMID: 34389694 Free PMC article.
TRAIL signaling promotes entosis in colorectal cancer.
Bozkurt E, Düssmann H, Salvucci M, Cavanagh BL, Van Schaeybroeck S, Longley DB, Martin SJ, Prehn JHM. Bozkurt E, et al. J Cell Biol. 2021 Nov 1;220(11):e202010030. doi: 10.1083/jcb.202010030. Epub 2021 Sep 21. J Cell Biol. 2021. PMID: 34546352 Free PMC article.
Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer.
Lawler M, Alsina D, Adams RA, Anderson AS, Brown G, Fearnhead NS, Fenwick SW, Halloran SP, Hochhauser D, Hull MA, Koelzer VH, McNair AGK, Monahan KJ, Näthke I, Norton C, Novelli MR, Steele RJC, Thomas AL, Wilde LM, Wilson RH, Tomlinson I; Bowel Cancer UK Critical Research Gaps in Colorectal Cancer Initiative. Lawler M, et al. Gut. 2018 Jan;67(1):179-193. doi: 10.1136/gutjnl-2017-315333. Gut. 2018. PMID: 29233930 Free PMC article. Review.
FLINO: a new method for immunofluorescence bioimage normalization.
Graf J, Cho S, McDonough E, Corwin A, Sood A, Lindner A, Salvucci M, Stachtea X, Van Schaeybroeck S, Dunne PD, Laurent-Puig P, Longley D, Prehn JHM, Ginty F. Graf J, et al. Bioinformatics. 2022 Jan 3;38(2):520-526. doi: 10.1093/bioinformatics/btab686. Bioinformatics. 2022. PMID: 34601553 Free PMC article.
Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer.
Corry SM, McCorry AM, Lannagan TR, Leonard NA, Fisher NC, Byrne RM, Tsantoulis P, Cortes-Lavaud X, Amirkhah R, Redmond KL, McCooey AJ, Malla SB, Rogan E, Sakhnevych S, Gillespie MA, White M, Richman SD, Jackstadt RF, Campbell AD, Maguire S; S:CORT and ACRCelerate consortia; McDade SS, Longley DB, Loughrey MB, Coleman HG, Kerr EM, Tejpar S, Maughan T, Leedham SJ, Small DM, Ryan AE, Sansom OJ, Lawler M, Dunne PD. Corry SM, et al. Gut. 2022 Dec;71(12):2502-2517. doi: 10.1136/gutjnl-2021-326183. Epub 2022 Apr 27. Gut. 2022. PMID: 35477539 Free PMC article.
22 results