084353/WT_/Wellcome Trust/United Kingdom[Grants and Funding] - Search Results

Year	Number of Results
2007	1
2008	1
2009	3
2010	6
2011	1
2012	1
2013	2
2025	0

1

The unfolded protein response and its relevance to connective tissue diseases.

Boot-Handford RP, Briggs MD. Boot-Handford RP, et al. Cell Tissue Res. 2010 Jan;339(1):197-211. doi: 10.1007/s00441-009-0877-8. Epub 2009 Oct 23. Cell Tissue Res. 2010. PMID: 19851784 Free PMC article. Review.

2

Armet/Manf and Creld2 are components of a specialized ER stress response provoked by inappropriate formation of disulphide bonds: implications for genetic skeletal diseases.

Hartley CL, Edwards S, Mullan L, Bell PA, Fresquet M, Boot-Handford RP, Briggs MD. Hartley CL, et al. Hum Mol Genet. 2013 Dec 20;22(25):5262-75. doi: 10.1093/hmg/ddt383. Epub 2013 Aug 15. Hum Mol Genet. 2013. PMID: 23956175 Free PMC article.

3

Structural and functional investigations of Matrilin-1 A-domains reveal insights into their role in cartilage ECM assembly.

Fresquet M, Jowitt TA, Stephen LA, Ylöstalo J, Briggs MD. Fresquet M, et al. J Biol Chem. 2010 Oct 29;285(44):34048-61. doi: 10.1074/jbc.M110.154443. Epub 2010 Aug 21. J Biol Chem. 2010. PMID: 20729554 Free PMC article.

4

A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth.

Gualeni B, Rajpar MH, Kellogg A, Bell PA, Arvan P, Boot-Handford RP, Briggs MD. Gualeni B, et al. Dis Model Mech. 2013 Nov;6(6):1414-25. doi: 10.1242/dmm.013342. Epub 2013 Sep 12. Dis Model Mech. 2013. PMID: 24046357 Free PMC article.

5

Hypertrophic chondrocytes have a limited capacity to cope with increases in endoplasmic reticulum stress without triggering the unfolded protein response.

Kung LH, Rajpar MH, Briggs MD, Boot-Handford RP. Kung LH, et al. J Histochem Cytochem. 2012 Oct;60(10):734-48. doi: 10.1369/0022155412458436. Epub 2012 Aug 1. J Histochem Cytochem. 2012. PMID: 22859705 Free PMC article.

6

Targeted induction of endoplasmic reticulum stress induces cartilage pathology.

Rajpar MH, McDermott B, Kung L, Eardley R, Knowles L, Heeran M, Thornton DJ, Wilson R, Bateman JF, Poulsom R, Arvan P, Kadler KE, Briggs MD, Boot-Handford RP. Rajpar MH, et al. PLoS Genet. 2009 Oct;5(10):e1000691. doi: 10.1371/journal.pgen.1000691. Epub 2009 Oct 16. PLoS Genet. 2009. PMID: 19834559 Free PMC article.

7

An unfolded protein response is the initial cellular response to the expression of mutant matrilin-3 in a mouse model of multiple epiphyseal dysplasia.

Nundlall S, Rajpar MH, Bell PA, Clowes C, Zeeff LA, Gardner B, Thornton DJ, Boot-Handford RP, Briggs MD. Nundlall S, et al. Cell Stress Chaperones. 2010 Nov;15(6):835-49. doi: 10.1007/s12192-010-0193-y. Epub 2010 Apr 30. Cell Stress Chaperones. 2010. PMID: 20428984 Free PMC article.

8

Collagen XXVII organises the pericellular matrix in the growth plate.

Plumb DA, Ferrara L, Torbica T, Knowles L, Mironov A Jr, Kadler KE, Briggs MD, Boot-Handford RP. Plumb DA, et al. PLoS One. 2011;6(12):e29422. doi: 10.1371/journal.pone.0029422. Epub 2011 Dec 19. PLoS One. 2011. PMID: 22206015 Free PMC article.

9

A recessive skeletal dysplasia, SEMD aggrecan type, results from a missense mutation affecting the C-type lectin domain of aggrecan.

Tompson SW, Merriman B, Funari VA, Fresquet M, Lachman RS, Rimoin DL, Nelson SF, Briggs MD, Cohn DH, Krakow D. Tompson SW, et al. Am J Hum Genet. 2009 Jan;84(1):72-9. doi: 10.1016/j.ajhg.2008.12.001. Epub 2008 Dec 24. Am J Hum Genet. 2009. PMID: 19110214 Free PMC article.

10

A mouse model offers novel insights into the myopathy and tendinopathy often associated with pseudoachondroplasia and multiple epiphyseal dysplasia.

Piróg KA, Jaka O, Katakura Y, Meadows RS, Kadler KE, Boot-Handford RP, Briggs MD. Piróg KA, et al. Hum Mol Genet. 2010 Jan 1;19(1):52-64. doi: 10.1093/hmg/ddp466. Hum Mol Genet. 2010. PMID: 19808781 Free PMC article.

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