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Page 1
A Deep Learning Approach to Antibiotic Discovery.
Stokes JM, Yang K, Swanson K, Jin W, Cubillos-Ruiz A, Donghia NM, MacNair CR, French S, Carfrae LA, Bloom-Ackermann Z, Tran VM, Chiappino-Pepe A, Badran AH, Andrews IW, Chory EJ, Church GM, Brown ED, Jaakkola TS, Barzilay R, Collins JJ. Stokes JM, et al. Cell. 2020 Feb 20;180(4):688-702.e13. doi: 10.1016/j.cell.2020.01.021. Cell. 2020. PMID: 32084340 Free PMC article.
Inhibiting fatty acid synthesis overcomes colistin resistance.
Carfrae LA, Rachwalski K, French S, Gordzevich R, Seidel L, Tsai CN, Tu MM, MacNair CR, Ovchinnikova OG, Clarke BR, Whitfield C, Brown ED. Carfrae LA, et al. Nat Microbiol. 2023 Jun;8(6):1026-1038. doi: 10.1038/s41564-023-01369-z. Epub 2023 May 1. Nat Microbiol. 2023. PMID: 37127701
Discovery of an antivirulence compound that reverses β-lactam resistance in MRSA.
El-Halfawy OM, Czarny TL, Flannagan RS, Day J, Bozelli JC Jr, Kuiack RC, Salim A, Eckert P, Epand RM, McGavin MJ, Organ MG, Heinrichs DE, Brown ED. El-Halfawy OM, et al. Nat Chem Biol. 2020 Feb;16(2):143-149. doi: 10.1038/s41589-019-0401-8. Epub 2019 Nov 25. Nat Chem Biol. 2020. PMID: 31768032
16 results