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12 results

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CHCHD2 mutant mice display mitochondrial protein accumulation and disrupted energy metabolism.
Liao SC, Kano K, Phanse S, Nguyen M, Margolis E, Fu Y, Meng J, Moutaoufik MT, Chatterton Z, Aoki H, Simms J, Hsieh I, Suteja F, Sei Y, Huang EJ, McAvoy K, Manfredi G, Halliday G, Babu M, Nakamura K. Liao SC, et al. Among authors: babu m. bioRxiv [Preprint]. 2024 Aug 31:2024.08.30.610586. doi: 10.1101/2024.08.30.610586. bioRxiv. 2024. PMID: 39257750 Free PMC article. Preprint.
As such, the CHCHD2 T61I point-mutation mice exhibit robust mitochondrial disruption and a consequent metabolic shift towards glycolysis. These findings thus establish CHCHD2 T61I mice as a new model for mitochondrial-based PD, and implicate disrupted respiratory chain fun …
As such, the CHCHD2 T61I point-mutation mice exhibit robust mitochondrial disruption and a consequent metabolic shift towards glycoly …
Unravelling the role of microneedles in drug delivery: Principle, perspectives, and practices.
Babu MR, Vishwas S, Khursheed R, Harish V, Sravani AB, Khan F, Alotaibi B, Binshaya A, Disouza J, Kumbhar PS, Patravale V, Gupta G, Loebenberg R, Arshad MF, Patel A, Patel S, Dua K, Singh SK. Babu MR, et al. Drug Deliv Transl Res. 2024 Jun;14(6):1393-1431. doi: 10.1007/s13346-023-01475-9. Epub 2023 Nov 30. Drug Deliv Transl Res. 2024. PMID: 38036849 Review.
In recent year, the research of transdermal drug delivery systems has got substantial attention towards the development of microneedles (MNs). This shift has occurred due to multifaceted advantages of MNs as they can be utilized to deliver the drug deeper to the skin with …
In recent year, the research of transdermal drug delivery systems has got substantial attention towards the development of microneedles (MNs …
Lithium-induced parathyroid dysfunction: A new case.
Nair CG, Menon R, Jacob P, Babu M. Nair CG, et al. Among authors: babu m. Indian J Endocrinol Metab. 2013 Sep;17(5):930-2. doi: 10.4103/2230-8210.117223. Indian J Endocrinol Metab. 2013. PMID: 24083184 Free PMC article.
Biochemical parameters showed hyperparathyroidism with shift of calcium creatinine clearance ratio to 0.013, indicating an error in threshold of calcium sensing receptor. ...
Biochemical parameters showed hyperparathyroidism with shift of calcium creatinine clearance ratio to 0.013, indicating an error in t …
Disorder-to-order transition in PE-PPE proteins of Mycobacterium tuberculosis augments the pro-pathogen immune response.
Ahmad J, Khubaib M, Sheikh JA, Pancsa R, Kumar S, Srinivasan A, Babu MM, Hasnain SE, Ehtesham NZ. Ahmad J, et al. Among authors: babu mm. FEBS Open Bio. 2020 Jan;10(1):70-85. doi: 10.1002/2211-5463.12749. Epub 2019 Dec 17. FEBS Open Bio. 2020. PMID: 31643141 Free PMC article.
These disordered proteins displayed a considerable structural shift from disordered to ordered while engaged in the formation of complexes. While these proteins are immunogenic individually and enhance the pro-pathogen response, their corresponding complexes enhanced the r …
These disordered proteins displayed a considerable structural shift from disordered to ordered while engaged in the formation of comp …
Cellular strategies for regulating functional and nonfunctional protein aggregation.
Gsponer J, Babu MM. Gsponer J, et al. Among authors: babu mm. Cell Rep. 2012 Nov 29;2(5):1425-37. doi: 10.1016/j.celrep.2012.09.036. Epub 2012 Nov 15. Cell Rep. 2012. PMID: 23168257 Free PMC article.
The trends are evolutionarily conserved and suggest a strategy whereby cellular mechanisms specifically modulate the availability of aggregation-prone proteins to (1) keep concentrations below the critical ones required for aggregation and (2) shift the equilibrium between …
The trends are evolutionarily conserved and suggest a strategy whereby cellular mechanisms specifically modulate the availability of aggrega …
Liquid biopsies and exosomal ncRNA: Transforming pancreatic cancer diagnostics and therapeutics.
Balaraman AK, Moglad E, Afzal M, Babu MA, Goyal K, Roopashree R, Kaur I, Kumar S, Kumar M, Chauhan AS, Hemalatha S, Gupta G, Ali H. Balaraman AK, et al. Among authors: babu ma. Clin Chim Acta. 2024 Dec 18;567:120105. doi: 10.1016/j.cca.2024.120105. Online ahead of print. Clin Chim Acta. 2024. PMID: 39706249 Review.
Emerging therapeutic strategies that target the immune response, epithelial-mesenchymal transition (EMT) and drug resistance are explored. This review demonstrates a paradigm shift in pancreatic cancer management toward personalized, less invasive and more effective approa …
Emerging therapeutic strategies that target the immune response, epithelial-mesenchymal transition (EMT) and drug resistance are explored. T …
Quercetin attenuates Monocyte Chemoattractant Protein-1 gene expression in glucose primed aortic endothelial cells through NF-kappaB and AP-1.
Panicker SR, Sreenivas P, Babu MS, Karunagaran D, Kartha CC. Panicker SR, et al. Among authors: babu ms. Pharmacol Res. 2010 Oct;62(4):328-36. doi: 10.1016/j.phrs.2010.06.003. Epub 2010 Jun 11. Pharmacol Res. 2010. PMID: 20542118
Quercetin was found to attenuate HG induced increased NF-kappaB and AP-1 DNA binding activity in electrophoretic mobility shift assay. Immunofluorescence studies revealed quercetin to prevent HG induced nuclear localization of p65 and c-jun. ...
Quercetin was found to attenuate HG induced increased NF-kappaB and AP-1 DNA binding activity in electrophoretic mobility shift assay …
Electronic structure transition of cubic CsSnCl3 under pressure: effect of rPBE and PBEsol functionals and GW method.
Babu MMH, Saha T, Podder J, Roy P, Barik A, Haque E. Babu MMH, et al. Heliyon. 2021 Aug 14;7(8):e07796. doi: 10.1016/j.heliyon.2021.e07796. eCollection 2021 Aug. Heliyon. 2021. PMID: 34466695 Free PMC article.
Afterward, we have also investigated the influence of pressure on absorption coefficient, and mechanical properties meticulously. Although the pressure shifts the absorption peak to lower photon energies, the absorption coefficient is slightly improved....
Afterward, we have also investigated the influence of pressure on absorption coefficient, and mechanical properties meticulously. Although t …
Recognition pliability is coupled to structural heterogeneity: a calmodulin intrinsically disordered binding region complex.
Nagulapalli M, Parigi G, Yuan J, Gsponer J, Deraos G, Bamm VV, Harauz G, Matsoukas J, de Planque MR, Gerothanassis IP, Babu MM, Luchinat C, Tzakos AG. Nagulapalli M, et al. Among authors: babu mm. Structure. 2012 Mar 7;20(3):522-33. doi: 10.1016/j.str.2012.01.021. Structure. 2012. PMID: 22405011 Free article.
To characterize this interaction, we implemented an NMR spectroscopic approach that calculates, for each conformation of the complex, the maximum occurrence based on recorded pseudocontact shifts and residual dipolar couplings. We found that the MBP(145-165)-calmodulin int …
To characterize this interaction, we implemented an NMR spectroscopic approach that calculates, for each conformation of the complex, the ma …
Studies on root anatomy, morphology and physiology of rice grown under aerobic and anaerobic conditions.
Phule AS, Barbadikar KM, Madhav MS, Subrahmanyam D, Senguttuvel P, Babu MBBP, Kumar PA. Phule AS, et al. Among authors: babu mbbp. Physiol Mol Biol Plants. 2019 Jan;25(1):197-205. doi: 10.1007/s12298-018-0599-z. Epub 2018 Sep 18. Physiol Mol Biol Plants. 2019. PMID: 30804642 Free PMC article.
With the changing climate and rainfall abrasions, there is a gradual shift in the system of rice cultivation from traditional transplanted anaerobic to aerobic system. ...
With the changing climate and rainfall abrasions, there is a gradual shift in the system of rice cultivation from traditional transpl …
12 results