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6,447 results

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Page 1
Characteristics of MK-801-induced locomotor sensitization.
Li G, Xu S, Kang UG. Li G, et al. Biochem Biophys Res Commun. 2023 Jul 30;667:18-24. doi: 10.1016/j.bbrc.2023.05.009. Epub 2023 May 11. Biochem Biophys Res Commun. 2023. PMID: 37201359
Repeated administration of drugs of abuse leads to progressively greater behavioral responses; this phenomenon is referred to as behavioral sensitization. MK-801 blocks the N-methyl-d-aspartate (NMDA) receptor and elicits behavioral sensitization. ...Following MK …
Repeated administration of drugs of abuse leads to progressively greater behavioral responses; this phenomenon is referred to as behavioral …
Recovery of NMDA receptor currents from MK-801 blockade is accelerated by Mg2+ and memantine under conditions of agonist exposure.
McKay S, Bengtson CP, Bading H, Wyllie DJ, Hardingham GE. McKay S, et al. Neuropharmacology. 2013 Nov;74:119-25. doi: 10.1016/j.neuropharm.2013.01.024. Epub 2013 Feb 10. Neuropharmacology. 2013. PMID: 23402996 Free PMC article.
MK-801 is a use-dependent NMDA receptor open channel blocker with a very slow off-rate. ...In the presence of Mg(2+), 50% recovery from MK-801 blockade is achieved after 10' of 100 muM NMDA, or 30' of 15 muM NMDA exposure. ...
MK-801 is a use-dependent NMDA receptor open channel blocker with a very slow off-rate. ...In the presence of Mg(2+), 50% reco …
Glycolytic and Krebs cycle enzymes activity in rat prefrontal cortex, hippocampus, and striatum after single and repeated NMDA inhibition by MK-801.
Kolar D, Kleteckova L, Skalova K, Brozka H, Kalous M, Vales K. Kolar D, et al. Neurotoxicology. 2022 May;90:35-47. doi: 10.1016/j.neuro.2022.02.005. Epub 2022 Feb 24. Neurotoxicology. 2022. PMID: 35219782
It was suggested that changes in energetic metabolism accompany psychosis and post-psychosis states. Here, we use the N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 to experimentally induce psychosis-like behavior in rats. ...In STR, a single MK-801 a …
It was suggested that changes in energetic metabolism accompany psychosis and post-psychosis states. Here, we use the N-methyl-D-aspartate ( …
NMDA Receptor Activation Stimulates Hypoxia-Induced TRPM2 Channel Activation, Mitochondrial Oxidative Stress, and Apoptosis in Neuronal Cell Line: Modular Role of Memantine.
Yıldızhan K, Nazıroğlu M. Yıldızhan K, et al. Brain Res. 2023 Mar 15;1803:148232. doi: 10.1016/j.brainres.2023.148232. Epub 2023 Jan 5. Brain Res. 2023. PMID: 36610553
The stimulations of the N-methyl-d-aspartate(NMDA) receptor and TRPM2 channel induce mROS and apoptosis in the neurons, although their inhibitions via the treatments of memantine (MEM) and MK-801 decrease mROS and apoptosis. ...Six groups were induced in the SH-SY5Y …
The stimulations of the N-methyl-d-aspartate(NMDA) receptor and TRPM2 channel induce mROS and apoptosis in the neurons, although thei …
Methyl Palmitate Modulated NMDA-Induced Cerebral Hyperemia in Hypertensive Rats.
Hsu CK, Chang SJ, Lim LY, Chang HH, Shei-Dei Yang S. Hsu CK, et al. J Vasc Res. 2023;60(3):137-147. doi: 10.1159/000529916. Epub 2023 Jun 7. J Vasc Res. 2023. PMID: 37285812
The increase in rCBF after the topical application of experimental drugs was measured using laser Doppler flowmetry. Topical NMDA application induced an MK-801-sensitive increase in rCBF in anesthetized WKY rats, which was inhibited by MP pretreatments. ...Neither M …
The increase in rCBF after the topical application of experimental drugs was measured using laser Doppler flowmetry. Topical NMDA app …
Reduction of NMDA receptors with dithiothreitol increases [3H]-MK-801 binding and NMDA-induced Ca2+ fluxes.
Reynolds IJ, Rush EA, Aizenman E. Reynolds IJ, et al. Br J Pharmacol. 1990 Sep;101(1):178-82. doi: 10.1111/j.1476-5381.1990.tb12109.x. Br J Pharmacol. 1990. PMID: 2149291 Free PMC article.
Increases in [3H]-MK-801 binding produced by glutamate, glycine and spermidine were enhanced by DTT (2mM) and diminished by DTNB (0.5 mM). 3. ...NMDA-induced Ca2+ fluxes into primary cultures of rat forebrain neurones were enhanced by DTT in a DTNB-reversible fashio …
Increases in [3H]-MK-801 binding produced by glutamate, glycine and spermidine were enhanced by DTT (2mM) and diminished by DTNB (0.5 …
The role of NMDA glutamate receptors in the lateral habenula on morphine-induced conditioned place preference in rats.
Amohashemi E, Reisi P, Alaei H. Amohashemi E, et al. Synapse. 2023 Sep;77(5):30-41. doi: 10.1002/syn.22273. Epub 2023 Apr 30. Synapse. 2023. PMID: 37122079
Bilateral injections of agonist/antagonist (MK-801) of NMDA receptor were performed during the conditioning sessions of the acquisition phase. ...The reduction effect of NMDA on the CPP scores during the acquisition phase was blocked by pretreatment with M …
Bilateral injections of agonist/antagonist (MK-801) of NMDA receptor were performed during the conditioning sessions of the ac …
Do NMDA-R antagonists re-create patterns of spontaneous gamma-band activity in schizophrenia? A systematic review and perspective.
Bianciardi B, Uhlhaas PJ. Bianciardi B, et al. Neurosci Biobehav Rev. 2021 May;124:308-323. doi: 10.1016/j.neubiorev.2021.02.005. Epub 2021 Feb 10. Neurosci Biobehav Rev. 2021. PMID: 33581223 Free article. Review.
NMDA-R hypofunctioninig is a core pathophysiological mechanism in schizophrenia. However, it is unclear whether the physiological changes observed following NMDA-R antagonist administration are consistent with gamma-band alterations in schizophrenia. This systematic …
NMDA-R hypofunctioninig is a core pathophysiological mechanism in schizophrenia. However, it is unclear whether the physiological cha …
Spinal administration of MK-801 and NBQX demonstrates NMDA-independent dorsal horn sensitization in incisional pain.
Zahn PK, Pogatzki-Zahn EM, Brennan TJ. Zahn PK, et al. Pain. 2005 Apr;114(3):499-510. doi: 10.1016/j.pain.2005.01.018. Pain. 2005. PMID: 15777875
. (+)-5-Methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine (MK-801) or 1 mM 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo[f]quinoxaline-7-sulfonamide (NBQX) was administered through a microdialysis fiber to block NMDA and nonNMDA EAA receptors, respectively. ...The m …
. (+)-5-Methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine (MK-801) or 1 mM 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo[f]quinoxalin …
Effects of NMDA and MK-801 injected into the substantia nigra pars reticulata on jaw movements evoked by dopamine D1-/D2 receptor stimulation in the ventrolateral striatum: studies in freely moving rats.
Uchida T, Lee J, Fujita S, Kiguchi M, Matsumoto M, Oi Y, Gionhaku N, Koshikawa N. Uchida T, et al. Methods Find Exp Clin Pharmacol. 2005 Jan-Feb;27(1):31-7. doi: 10.1358/mf.2005.27.1.875434. Methods Find Exp Clin Pharmacol. 2005. PMID: 15834457 Free article.
The effects of NMDA and MK-801 injected into the substantia nigra pars reticulata on jaw movements evoked by dopamine D1/D2 receptor stimulation in the ventrolateral striatum were examined in freely moving rats, by using a magnet-sensing system combined with intrace …
The effects of NMDA and MK-801 injected into the substantia nigra pars reticulata on jaw movements evoked by dopamine D1/D2 re …
6,447 results