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Synthesis of USC-093 and comparison with its promoiety enantiomer USC-093D against adenovirus in vitro and in a Syrian hamster model.
Yang J, Riemann SB, Lyu J, Feng S, Bi Y, Lentini NA, Kang I, Kashemirov BA, Hartline CB, James SH, Tollefson AE, Cline-Smith A, Toth K, McKenna CE. Yang J, et al. bioRxiv [Preprint]. 2024 Nov 1:2024.11.01.621456. doi: 10.1101/2024.11.01.621456. bioRxiv. 2024. PMID: 39554161 Free PMC article. Preprint.
In this study, the hamsters were instilled i.n. with vehicle or 4X10 (10) PFU/kg of HAdV-C6 to promote lung infection. Oral valganciclovir (VGCV) at 200 mg/kg b.i.d. was used as the positive control. The body weights were recorded daily, and at 3 days post challenge, gross …
In this study, the hamsters were instilled i.n. with vehicle or 4X10 (10) PFU/kg of HAdV-C6 to promote lung infection. Oral valganciclovir ( …