Kunze KL - Search Results

1

Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression.

Gibbs MA, Thummel KE, Shen DD, Kunze KL. Gibbs MA, et al. Among authors: kunze kl. Drug Metab Dispos. 1999 Feb;27(2):180-7. Drug Metab Dispos. 1999. PMID: 9929500

2

Role of itraconazole metabolites in CYP3A4 inhibition.

Isoherranen N, Kunze KL, Allen KE, Nelson WL, Thummel KE. Isoherranen N, et al. Among authors: kunze kl. Drug Metab Dispos. 2004 Oct;32(10):1121-31. doi: 10.1124/dmd.104.000315. Epub 2004 Jul 8. Drug Metab Dispos. 2004. PMID: 15242978

3

Differences in the inhibition of cytochromes P450 3A4 and 3A5 by metabolite-inhibitor complex-forming drugs.

McConn DJ 2nd, Lin YS, Allen K, Kunze KL, Thummel KE. McConn DJ 2nd, et al. Among authors: kunze kl. Drug Metab Dispos. 2004 Oct;32(10):1083-91. doi: 10.1124/dmd.32.10.. Drug Metab Dispos. 2004. PMID: 15377640

4

Stereochemical aspects of itraconazole metabolism in vitro and in vivo.

Kunze KL, Nelson WL, Kharasch ED, Thummel KE, Isoherranen N. Kunze KL, et al. Drug Metab Dispos. 2006 Apr;34(4):583-90. doi: 10.1124/dmd.105.008508. Epub 2006 Jan 13. Drug Metab Dispos. 2006. PMID: 16415110 Clinical Trial.

5

Human liver microsomal enflurane defluorination catalyzed by cytochrome P-450 2E1.

Thummel KE, Kharasch ED, Podoll T, Kunze K. Thummel KE, et al. Drug Metab Dispos. 1993 Mar-Apr;21(2):350-7. Drug Metab Dispos. 1993. PMID: 8097708

6

Catalytic role of cytochrome P4503A4 in multiple pathways of alfentanil metabolism.

Labroo RB, Thummel KE, Kunze KL, Podoll T, Trager WF, Kharasch ED. Labroo RB, et al. Among authors: kunze kl. Drug Metab Dispos. 1995 Apr;23(4):490-6. Drug Metab Dispos. 1995. PMID: 7600917

7

Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Lack of prediction by the erythromycin breath test.

Lown KS, Kolars JC, Thummel KE, Barnett JL, Kunze KL, Wrighton SA, Watkins PB. Lown KS, et al. Among authors: kunze kl. Drug Metab Dispos. 1994 Nov-Dec;22(6):947-55. Drug Metab Dispos. 1994. PMID: 7895614

8

Use of midazolam as a human cytochrome P450 3A probe: I. In vitro-in vivo correlations in liver transplant patients.

Thummel KE, Shen DD, Podoll TD, Kunze KL, Trager WF, Hartwell PS, Raisys VA, Marsh CL, McVicar JP, Barr DM, et al. Thummel KE, et al. Among authors: kunze kl. J Pharmacol Exp Ther. 1994 Oct;271(1):549-56. J Pharmacol Exp Ther. 1994. PMID: 7965755

9

Use of midazolam as a human cytochrome P450 3A probe: II. Characterization of inter- and intraindividual hepatic CYP3A variability after liver transplantation.

Thummel KE, Shen DD, Podoll TD, Kunze KL, Trager WF, Bacchi CE, Marsh CL, McVicar JP, Barr DM, Perkins JD, et al. Thummel KE, et al. Among authors: kunze kl. J Pharmacol Exp Ther. 1994 Oct;271(1):557-66. J Pharmacol Exp Ther. 1994. PMID: 7965756

10

Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by human CYP3A4.

Thummel KE, Lee CA, Kunze KL, Nelson SD, Slattery JT. Thummel KE, et al. Among authors: kunze kl. Biochem Pharmacol. 1993 Apr 22;45(8):1563-9. doi: 10.1016/0006-2952(93)90295-8. Biochem Pharmacol. 1993. PMID: 8387297

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