Deletion of amino acids 261-269 in the brown fat uncoupling protein converts the carrier into a pore.
González-Barroso MM, Fleury C, Levi-Meyrueis C, Zaragoza P, Bouillaud F, Rial E.
González-Barroso MM, et al. Among authors: bouillaud f.
Biochemistry. 1997 Sep 9;36(36):10930-5. doi: 10.1021/bi971104y.
Biochemistry. 1997.
PMID: 9283084
Site-directed mutagenesis of the UCP showed that deletion of amino acids 267-269 in the UCP abolished nucleotide inhibition [Bouillaud, F., et al. (1994) EMBO J. 13, 1990-1997]. Complete deletion of the homologous domain (UCPDelta9) produced a highly deleterious mut …
Site-directed mutagenesis of the UCP showed that deletion of amino acids 267-269 in the UCP abolished nucleotide inhibition [Bouillaud …