Laver WG - Search Results

1

A new series of C3-aza carbocyclic influenza neuraminidase inhibitors: synthesis and inhibitory activity.

Lew W, Wu H, Mendel DB, Escarpe PA, Chen X, Laver WG, Graves BJ, Kim CU. Lew W, et al. Among authors: laver wg. Bioorg Med Chem Lett. 1998 Dec 1;8(23):3321-4. doi: 10.1016/s0960-894x(98)00587-3. Bioorg Med Chem Lett. 1998. PMID: 9873727

2

Structure-activity relationship studies of novel carbocyclic influenza neuraminidase inhibitors.

Kim CU, Lew W, Williams MA, Wu H, Zhang L, Chen X, Escarpe PA, Mendel DB, Laver WG, Stevens RC. Kim CU, et al. Among authors: laver wg. J Med Chem. 1998 Jul 2;41(14):2451-60. doi: 10.1021/jm980162u. J Med Chem. 1998. PMID: 9651151

3

Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity.

Kim CU, Lew W, Williams MA, Liu H, Zhang L, Swaminathan S, Bischofberger N, Chen MS, Mendel DB, Tai CY, Laver WG, Stevens RC. Kim CU, et al. Among authors: laver wg. J Am Chem Soc. 1997 Jan 29;119(4):681-90. doi: 10.1021/ja963036t. J Am Chem Soc. 1997. PMID: 16526129

4

Design, synthesis, and neuraminidase inhibitory activity of GS-4071 analogues that utilize a novel hydrophobic paradigm.

Hanessian S, Wang J, Montgomery D, Stoll V, Stewart KD, Kati W, Maring C, Kempf D, Hutchins C, Laver WG. Hanessian S, et al. Among authors: laver wg. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3425-9. doi: 10.1016/s0960-894x(02)00732-1. Bioorg Med Chem Lett. 2002. PMID: 12419376

5

Novel alpha- and beta-amino acid inhibitors of influenza virus neuraminidase.

Kati WM, Montgomery D, Maring C, Stoll VS, Giranda V, Chen X, Laver WG, Kohlbrenner W, Norbeck DW. Kati WM, et al. Among authors: laver wg. Antimicrob Agents Chemother. 2001 Sep;45(9):2563-70. doi: 10.1128/AAC.45.9.2563-2570.2001. Antimicrob Agents Chemother. 2001. PMID: 11502530 Free PMC article.

6

Design, synthesis, and structural analysis of influenza neuraminidase inhibitors containing pyrrolidine cores.

Wang GT, Chen Y, Wang S, Gentles R, Sowin T, Kati W, Muchmore S, Giranda V, Stewart K, Sham H, Kempf D, Laver WG. Wang GT, et al. Among authors: laver wg. J Med Chem. 2001 Apr 12;44(8):1192-201. doi: 10.1021/jm000468c. J Med Chem. 2001. PMID: 11312919

7

Design and synthesis of benzoic acid derivatives as influenza neuraminidase inhibitors using structure-based drug design.

Chand P, Babu YS, Bantia S, Chu N, Cole LB, Kotian PL, Laver WG, Montgomery JA, Pathak VP, Petty SL, Shrout DP, Walsh DA, Walsh GM. Chand P, et al. Among authors: laver wg. J Med Chem. 1997 Dec 5;40(25):4030-52. doi: 10.1021/jm970479e. J Med Chem. 1997. PMID: 9406595

8

Structure-based characterization and optimization of novel hydrophobic binding interactions in a series of pyrrolidine influenza neuraminidase inhibitors.

Maring CJ, Stoll VS, Zhao C, Sun M, Krueger AC, Stewart KD, Madigan DL, Kati WM, Xu Y, Carrick RJ, Montgomery DA, Kempf-Grote A, Marsh KC, Molla A, Steffy KR, Sham HL, Laver WG, Gu YG, Kempf DJ, Kohlbrenner WE. Maring CJ, et al. Among authors: laver wg. J Med Chem. 2005 Jun 16;48(12):3980-90. doi: 10.1021/jm049276y. J Med Chem. 2005. PMID: 15943472

9

Structure-based inhibitors of influenza virus sialidase. A benzoic acid lead with novel interaction.

Singh S, Jedrzejas MJ, Air GM, Luo M, Laver WG, Brouillette WJ. Singh S, et al. Among authors: laver wg. J Med Chem. 1995 Aug 18;38(17):3217-25. doi: 10.1021/jm00017a005. J Med Chem. 1995. PMID: 7650674

10

Guanidinobenzoic acid inhibitors of influenza virus neuraminidase.

Sudbeck EA, Jedrzejas MJ, Singh S, Brouillette WJ, Air GM, Laver WG, Babu YS, Bantia S, Chand P, Chu N, Montgomery JA, Walsh DA, Luo M. Sudbeck EA, et al. Among authors: laver wg. J Mol Biol. 1997 Apr 4;267(3):584-94. doi: 10.1006/jmbi.1996.0885. J Mol Biol. 1997. PMID: 9126840

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