Graves BJ - Search Results

1

A new series of C3-aza carbocyclic influenza neuraminidase inhibitors: synthesis and inhibitory activity.

Lew W, Wu H, Mendel DB, Escarpe PA, Chen X, Laver WG, Graves BJ, Kim CU. Lew W, et al. Among authors: graves bj. Bioorg Med Chem Lett. 1998 Dec 1;8(23):3321-4. doi: 10.1016/s0960-894x(98)00587-3. Bioorg Med Chem Lett. 1998. PMID: 9873727

2

Synthesis and evaluation of 1,4,5,6-tetrahydropyridazine derivatives as influenza neuraminidase inhibitors.

Zhang L, Williams MA, Mendel DB, Escarpe PA, Chen X, Wang KY, Graves BJ, Lawton G, Kim CU. Zhang L, et al. Among authors: graves bj. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1751-6. doi: 10.1016/s0960-894x(99)00280-2. Bioorg Med Chem Lett. 1999. PMID: 10406636

3

Carbocyclic influenza neuraminidase inhibitors possessing a C3-cyclic amine side chain: synthesis and inhibitory activity.

Lew W, Wu H, Chen X, Graves BJ, Escarpe PA, MacArthur HL, Mendel DB, Kim CU. Lew W, et al. Among authors: graves bj. Bioorg Med Chem Lett. 2000 Jun 5;10(11):1257-60. doi: 10.1016/s0960-894x(00)00214-6. Bioorg Med Chem Lett. 2000. PMID: 10866394

4

Novel binding mode of highly potent HIV-proteinase inhibitors incorporating the (R)-hydroxyethylamine isostere.

Krohn A, Redshaw S, Ritchie JC, Graves BJ, Hatada MH. Krohn A, et al. Among authors: graves bj. J Med Chem. 1991 Nov;34(11):3340-2. doi: 10.1021/jm00115a028. J Med Chem. 1991. PMID: 1956054 No abstract available.

5

Optimization of small molecule drugs binding to highly polar target sites: lessons from the discovery and development of neuraminidase inhibitors.

Klumpp K, Graves BJ. Klumpp K, et al. Among authors: graves bj. Curr Top Med Chem. 2006;6(5):423-34. doi: 10.2174/156802606776743138. Curr Top Med Chem. 2006. PMID: 16719801 Review.

6

Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity.

Chu XJ, DePinto W, Bartkovitz D, So SS, Vu BT, Packman K, Lukacs C, Ding Q, Jiang N, Wang K, Goelzer P, Yin X, Smith MA, Higgins BX, Chen Y, Xiang Q, Moliterni J, Kaplan G, Graves B, Lovey A, Fotouhi N. Chu XJ, et al. J Med Chem. 2006 Nov 2;49(22):6549-60. doi: 10.1021/jm0606138. J Med Chem. 2006. PMID: 17064073

7

Orally absorbable cephalosporin antibiotics. 1. Structure-activity relationships of benzothienyl- and naphthylglycine derivatives of 7-aminodeacetoxycephalosporanic acid.

Kukolja S, Draheim SE, Pfeil JL, Cooper RD, Graves BJ, Holmes RE, Neel DA, Huffman GW, Webber JA, Kinnick MD, et al. Kukolja S, et al. Among authors: graves bj. J Med Chem. 1985 Dec;28(12):1886-96. doi: 10.1021/jm00150a022. J Med Chem. 1985. PMID: 2933519

8

Concepts and progress in the development of peptide mimetics.

Olson GL, Bolin DR, Bonner MP, Bös M, Cook CM, Fry DC, Graves BJ, Hatada M, Hill DE, Kahn M, et al. Olson GL, et al. Among authors: graves bj. J Med Chem. 1993 Oct 15;36(21):3039-49. doi: 10.1021/jm00073a001. J Med Chem. 1993. PMID: 8230089 Review. No abstract available.

9

Orally absorbable cephalosporin antibiotics. 2. Structure-activity studies of bicyclic glycine derivatives of 7-aminodeacetoxycephalosporanic acid.

Kukolja S, Draheim SE, Graves BJ, Hunden DC, Pfeil JL, Cooper RD, Ott JL, Counter FT. Kukolja S, et al. Among authors: graves bj. J Med Chem. 1985 Dec;28(12):1896-903. doi: 10.1021/jm00150a023. J Med Chem. 1985. PMID: 3877809

10

Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase.

Goldstein DM, Soth M, Gabriel T, Dewdney N, Kuglstatter A, Arzeno H, Chen J, Bingenheimer W, Dalrymple SA, Dunn J, Farrell R, Frauchiger S, La Fargue J, Ghate M, Graves B, Hill RJ, Li F, Litman R, Loe B, McIntosh J, McWeeney D, Papp E, Park J, Reese HF, Roberts RT, Rotstein D, San Pablo B, Sarma K, Stahl M, Sung ML, Suttman RT, Sjogren EB, Tan Y, Trejo A, Welch M, Weller P, Wong BR, Zecic H. Goldstein DM, et al. J Med Chem. 2011 Apr 14;54(7):2255-65. doi: 10.1021/jm101423y. Epub 2011 Mar 4. J Med Chem. 2011. PMID: 21375264

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