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Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice.
Holladay MW, Bai H, Li Y, Lin NH, Daanen JF, Ryther KB, Wasicak JT, Kincaid JF, He Y, Hettinger AM, Huang P, Anderson DJ, Bannon AW, Buckley MJ, Campbell JE, Donnelly-Roberts DL, Gunther KL, Kim DJ, Kuntzweiler TA, Sullivan JP, Decker MW, Arneric SP. Holladay MW, et al. Among authors: buckley mj. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2797-802. doi: 10.1016/s0960-894x(98)00504-6. Bioorg Med Chem Lett. 1998. PMID: 9873625
Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors.
Bunnelle WH, Daanen JF, Ryther KB, Schrimpf MR, Dart MJ, Gelain A, Meyer MD, Frost JM, Anderson DJ, Buckley M, Curzon P, Cao YJ, Puttfarcken P, Searle X, Ji J, Putman CB, Surowy C, Toma L, Barlocco D. Bunnelle WH, et al. Among authors: buckley m. J Med Chem. 2007 Jul 26;50(15):3627-44. doi: 10.1021/jm070018l. Epub 2007 Jun 22. J Med Chem. 2007. PMID: 17585748
ABT-089: pharmacological properties of a neuronal nicotinic acetylcholine receptor agonist for the potential treatment of cognitive disorders.
Rueter LE, Anderson DJ, Briggs CA, Donnelly-Roberts DL, Gintant GA, Gopalakrishnan M, Lin NH, Osinski MA, Reinhart GA, Buckley MJ, Martin RL, McDermott JS, Preusser LC, Seifert TR, Su Z, Cox BF, Decker MW, Sullivan JP. Rueter LE, et al. Among authors: buckley mj. CNS Drug Rev. 2004 Summer;10(2):167-82. doi: 10.1111/j.1527-3458.2004.tb00011.x. CNS Drug Rev. 2004. PMID: 15179445 Free PMC article. Review.
Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties.
Lin NH, Gunn DE, Ryther KB, Garvey DS, Donnelly-Roberts DL, Decker MW, Brioni JD, Buckley MJ, Rodrigues AD, Marsh KG, Anderson DJ, Buccafusco JJ, Prendergast MA, Sullivan JP, Williams M, Arneric SP, Holladay MW. Lin NH, et al. Among authors: buckley mj. J Med Chem. 1997 Jan 31;40(3):385-90. doi: 10.1021/jm960233u. J Med Chem. 1997. PMID: 9022806
Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors.
Holladay MW, Wasicak JT, Lin NH, He Y, Ryther KB, Bannon AW, Buckley MJ, Kim DJ, Decker MW, Anderson DJ, Campbell JE, Kuntzweiler TA, Donnelly-Roberts DL, Piattoni-Kaplan M, Briggs CA, Williams M, Arneric SP. Holladay MW, et al. Among authors: buckley mj. J Med Chem. 1998 Feb 12;41(4):407-12. doi: 10.1021/jm9706224. J Med Chem. 1998. PMID: 9484491
ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective antinociceptive agent acting via neuronal nicotinic acetylcholine receptors: II. In vivo characterization.
Bannon AW, Decker MW, Curzon P, Buckley MJ, Kim DJ, Radek RJ, Lynch JK, Wasicak JT, Lin NH, Arnold WH, Holladay MW, Williams M, Arneric SP. Bannon AW, et al. Among authors: buckley mj. J Pharmacol Exp Ther. 1998 May;285(2):787-94. J Pharmacol Exp Ther. 1998. PMID: 9580627
391 results