Pitts WJ - Search Results

1

Structure-activity relationships (SAR) of some tetracyclic heterocycles related to the immunosuppressive agent Brequinar Sodium.

Pitts WJ, Jetter JW, Pinto DJ, Orwat MJ, Batt DG, Sherk SR, Petraitis JJ, Jacobson IC, Copeland RA, Dowling RL, Jaffee BD, Gardner TL, Jones EA, Magolda RL. Pitts WJ, et al. Bioorg Med Chem Lett. 1998 Feb 3;8(3):307-12. doi: 10.1016/s0960-894x(98)00010-9. Bioorg Med Chem Lett. 1998. PMID: 9871675

2

The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase.

Davis JP, Cain GA, Pitts WJ, Magolda RL, Copeland RA. Davis JP, et al. Among authors: pitts wj. Biochemistry. 1996 Jan 30;35(4):1270-3. doi: 10.1021/bi952168g. Biochemistry. 1996. PMID: 8573583

3

Terphenyl cyclooxygenase-2 (COX-2) inhibitors: optimization of the central ring and o-biphenyl analogs.

Pinto DJ, Batt DG, Pitts WJ, Petraitis JJ, Orwat MJ, Wang S, Jetter JW, Sherk SR, Houghton GC, Copeland RA, Covington MB, Trzaskos JM, Magolda RL. Pinto DJ, et al. Among authors: pitts wj. Bioorg Med Chem Lett. 1999 Apr 5;9(7):919-24. doi: 10.1016/s0960-894x(99)00105-5. Bioorg Med Chem Lett. 1999. PMID: 10230611

4

Rapid synthesis of RGD mimetics with isoxazoline scaffolds on solid phase: identification of alphavbeta3 antagonists lead compounds.

Rockwell AL, Rafalski M, Pitts WJ, Batt DG, Petraitis JJ, DeGrado WF, Mousa S, Jadhav PK. Rockwell AL, et al. Among authors: pitts wj. Bioorg Med Chem Lett. 1999 Apr 5;9(7):937-42. doi: 10.1016/s0960-894x(99)00114-6. Bioorg Med Chem Lett. 1999. PMID: 10230615

5

MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products.

Duncia JV, Santella JB 3rd, Higley CA, Pitts WJ, Wityak J, Frietze WE, Rankin FW, Sun JH, Earl RA, Tabaka AC, Teleha CA, Blom KF, Favata MF, Manos EJ, Daulerio AJ, Stradley DA, Horiuchi K, Copeland RA, Scherle PA, Trzaskos JM, Magolda RL, Trainor GL, Wexler RR, Hobbs FW, Olson RE. Duncia JV, et al. Among authors: pitts wj. Bioorg Med Chem Lett. 1998 Oct 20;8(20):2839-44. doi: 10.1016/s0960-894x(98)00522-8. Bioorg Med Chem Lett. 1998. PMID: 9873633

6

Isoxazolines as potent antagonists of the integrin alpha(v)beta(3).

Pitts WJ, Wityak J, Smallheer JM, Tobin AE, Jetter JW, Buynitsky JS, Harlow PP, Solomon KA, Corjay MH, Mousa SA, Wexler RR, Jadhav PK. Pitts WJ, et al. J Med Chem. 2000 Jan 13;43(1):27-40. doi: 10.1021/jm9900321. J Med Chem. 2000. PMID: 10633036

7

Identification of a novel inhibitor of mitogen-activated protein kinase kinase.

Favata MF, Horiuchi KY, Manos EJ, Daulerio AJ, Stradley DA, Feeser WS, Van Dyk DE, Pitts WJ, Earl RA, Hobbs F, Copeland RA, Magolda RL, Scherle PA, Trzaskos JM. Favata MF, et al. Among authors: pitts wj. J Biol Chem. 1998 Jul 17;273(29):18623-32. doi: 10.1074/jbc.273.29.18623. J Biol Chem. 1998. PMID: 9660836 Free article.

8

Novel diamide-based inhibitors of IMPDH.

Gu HH, Iwanowicz EJ, Guo J, Watterson SH, Shen Z, Pitts WJ, Dhar TG, Fleener CA, Rouleau K, Sherbina NZ, Witmer M, Tredup J, Hollenbaugh D. Gu HH, et al. Among authors: pitts wj. Bioorg Med Chem Lett. 2002 May 6;12(9):1323-6. doi: 10.1016/s0960-894x(02)00132-4. Bioorg Med Chem Lett. 2002. PMID: 11965381

9

A survey of cyclic replacements for the central diamide moiety of inhibitors of inosine monophosphate dehydrogenase.

Dhar TG, Liu C, Pitts WJ, Guo J, Watterson SH, Gu H, Fleener CA, Rouleau K, Sherbina NZ, Barrish JC, Hollenbaugh D, Iwanowicz EJ. Dhar TG, et al. Among authors: pitts wj. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3125-8. doi: 10.1016/s0960-894x(02)00641-8. Bioorg Med Chem Lett. 2002. PMID: 12372516

10

Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): synthesis and initial structure-activity relationships.

Kempson J, Pitts WJ, Barbosa J, Guo J, Omotoso O, Watson A, Stebbins K, Starling GC, Dodd JH, Barrish JC, Felix R, Fischer K. Kempson J, et al. Among authors: pitts wj. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1829-33. doi: 10.1016/j.bmcl.2005.02.025. Bioorg Med Chem Lett. 2005. PMID: 15780616

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