Miura D - Search Results

1

A novel and practical route to A-ring enyne synthon for 1 alpha,25-dihydroxyvitamin D3 analogs: synthesis of A-ring diastereomers of 1 alpha,25-dihydroxyvitamin D2 and 3-methyl-1,25-dihydroxyvitamin D3.

Konno K, Maki S, Fujishima T, Liu Z, Miura D, Chokki M, Takayama H. Konno K, et al. Among authors: miura d. Bioorg Med Chem Lett. 1998 Jan 20;8(2):151-6. doi: 10.1016/s0960-894x(97)10204-9. Bioorg Med Chem Lett. 1998. PMID: 9871644

2

Synthesis and biological activity of 2-methyl-20-epi analogues of 1 alpha,25-dihydroxyvitamin D3.

Fujishima T, Liu Z, Miura D, Chokki M, Ishizuka S, Konno K, Takayama H. Fujishima T, et al. Among authors: miura d. Bioorg Med Chem Lett. 1998 Aug 18;8(16):2145-8. doi: 10.1016/s0960-894x(98)00363-1. Bioorg Med Chem Lett. 1998. PMID: 9873502

3

Synthesis, biological evaluation, and conformational analysis of A-ring diastereomers of 2-methyl-1,25-dihydroxyvitamin D(3) and their 20-epimers: unique activity profiles depending on the stereochemistry of the A-ring and at C-20.

Konno K, Fujishima T, Maki S, Liu Z, Miura D, Chokki M, Ishizuka S, Yamaguchi K, Kan Y, Kurihara M, Miyata N, Smith C, DeLuca HF, Takayama H. Konno K, et al. Among authors: miura d. J Med Chem. 2000 Nov 2;43(22):4247-65. doi: 10.1021/jm000261j. J Med Chem. 2000. PMID: 11063621

4

Systematic studies on synthesis, structural elucidation, and biological evaluation of A-ring diastereomers of 2-methyl-1alpha,25-dihydroxyvitamin D(3) and 20-epi-2-methyl-1alpha,25-dihydroxyvitamin D(3).

Takayama H, Konno K, Fujishima T, Maki S, Liu Z, Miura D, Chokki M, Ishizuka S, Smith C, DeLuca HF, Nakagawa K, Kurobe M, Okano T. Takayama H, et al. Among authors: miura d. Steroids. 2001 Mar-May;66(3-5):277-85. doi: 10.1016/s0039-128x(00)00141-0. Steroids. 2001. PMID: 11179735

5

Dramatic enhancement of antagonistic activity on vitamin D receptor: a double functionalization of 1alpha-hydroxyvitamin D3 26,23-lactones.

Saito N, Saito H, Anzai M, Yoshida A, Fujishima T, Takenouchi K, Miura D, Ishizuka S, Takayama H, Kittaka A. Saito N, et al. Among authors: miura d. Org Lett. 2003 Dec 11;5(25):4859-62. doi: 10.1021/ol035922w. Org Lett. 2003. PMID: 14653692

6

Remarkable effect of 2[small alpha]-modification on the VDR antagonistic activity of 1small alpha-hydroxyvitamin D3-26,23-lactones.

Saito N, Matsunaga T, Fujishima T, Anzai M, Saito H, Takenouchi K, Miura D, Ishizuka S, Takayama H, Kittaka A. Saito N, et al. Among authors: miura d. Org Biomol Chem. 2003 Dec 21;1(24):4396-402. doi: 10.1039/b311107e. Epub 2003 Nov 6. Org Biomol Chem. 2003. PMID: 14685312

7

The antagonism between 2-methyl-1,25-dihydroxyvitamin D3 and 2-methyl-20-epi-1,25-dihydroxyvitamin D3 in non-genomic pathway-mediated biological responses induced by 1alpha,25-dihydroxyvitamin D3 assessed by NB4 cell differentiation.

Miura D, Norman AW, Mizwicki MT, Fujishima T, Konno K, Kittaka A, Takayama H, Ishizuka S. Miura D, et al. J Steroid Biochem Mol Biol. 2005 Apr;94(5):469-79. doi: 10.1016/j.jsbmb.2005.01.025. Epub 2005 Mar 17. J Steroid Biochem Mol Biol. 2005. PMID: 15876412

8

Antagonistic action of novel 1alpha,25-dihydroxyvitamin D(3)-26, 23-lactone analogs on 25-hydroxyvitamin-D(3)-24-hydroxylase gene expression induced by 1alpha,25-dihydroxy-vitamin D(3) in human promyelocytic leukemia (HL-60) cells.

Ishizuka S, Miura D, Eguchi H, Ozono K, Chokki M, Kamimura T, Norman AW. Ishizuka S, et al. Among authors: miura d. Arch Biochem Biophys. 2000 Aug 1;380(1):92-102. doi: 10.1006/abbi.2000.1902. Arch Biochem Biophys. 2000. PMID: 10900137

We have demonstrated that 1alpha,25-dihydroxyvitamin D(3)-26, 23-lactone analogs, (23S)- and (23R)-25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactone (TEI-9647, TEI-9648, respectively), inhibit HL-60 cell differentiation induced by 1alpha,25-dihydroxyvitamin D …

We have demonstrated that 1alpha,25-dihydroxyvitamin D(3)-26, 23-lactone analogs, (23S)- and (23R)-25-dehydro-1alpha-hydroxyvitamin …

9

Further synthetic and biological studies on vitamin D hormone antagonists based on C24-alkylation and C2alpha-functionalization of 25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactones.

Saito N, Matsunaga T, Saito H, Anzai M, Takenouchi K, Miura D, Namekawa J, Ishizuka S, Kittaka A. Saito N, et al. Among authors: miura d. J Med Chem. 2006 Nov 30;49(24):7063-75. doi: 10.1021/jm060797q. J Med Chem. 2006. PMID: 17125259

10

Antagonistic Actions in Vivo of (23S)-25-Dehydro-1alpha-Hydroxyvitamin D(3-)26,23-Lactone on Calcium Metabolism Induced by 1alpha,25-Dihydroxyvitamin D(3).

Ishizuka S, Miura D, Ozono K, Chokki M, Mimura H, Norman AW. Ishizuka S, et al. Among authors: miura d. Endocrinology. 2001 Jan;142(1):59-67. doi: 10.1210/endo.142.1.7925. Endocrinology. 2001. PMID: 11145567

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