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Novel ring A stereoisomers of 2-methyl-1alpha,25-dihydroxyvitamin D(3) and 2-methyl-20-epi-1alpha,25-dihydroxyvitamin D(3): transactivation of target genes and modulation of differentiation in human promyelocytic leukemia (HL-60) cells.
Nakagawa K, Kurobe M, Ozono K, Konno K, Fujishima T, Takayama H, Okano T. Nakagawa K, et al. Among authors: konno k. Biochem Pharmacol. 2000 Mar 15;59(6):691-702. doi: 10.1016/s0006-2952(99)00357-3. Biochem Pharmacol. 2000. PMID: 10677586
Synthesis, biological evaluation, and conformational analysis of A-ring diastereomers of 2-methyl-1,25-dihydroxyvitamin D(3) and their 20-epimers: unique activity profiles depending on the stereochemistry of the A-ring and at C-20.
Konno K, Fujishima T, Maki S, Liu Z, Miura D, Chokki M, Ishizuka S, Yamaguchi K, Kan Y, Kurihara M, Miyata N, Smith C, DeLuca HF, Takayama H. Konno K, et al. J Med Chem. 2000 Nov 2;43(22):4247-65. doi: 10.1021/jm000261j. J Med Chem. 2000. PMID: 11063621
Systematic studies on synthesis, structural elucidation, and biological evaluation of A-ring diastereomers of 2-methyl-1alpha,25-dihydroxyvitamin D(3) and 20-epi-2-methyl-1alpha,25-dihydroxyvitamin D(3).
Takayama H, Konno K, Fujishima T, Maki S, Liu Z, Miura D, Chokki M, Ishizuka S, Smith C, DeLuca HF, Nakagawa K, Kurobe M, Okano T. Takayama H, et al. Among authors: konno k. Steroids. 2001 Mar-May;66(3-5):277-85. doi: 10.1016/s0039-128x(00)00141-0. Steroids. 2001. PMID: 11179735
1,071 results