Gluchowski C - Search Results

1

Design and synthesis of novel alpha1a adrenoceptor-selective dihydropyridine antagonists for the treatment of benign prostatic hyperplasia.

Nagarathnam D, Wetzel JM, Miao SW, Marzabadi MR, Chiu G, Wong WC, Hong X, Fang J, Forray C, Branchek TA, Heydorn WE, Chang RS, Broten T, Schorn TW, Gluchowski C. Nagarathnam D, et al. Among authors: gluchowski c. J Med Chem. 1998 Dec 17;41(26):5320-33. doi: 10.1021/jm980506g. J Med Chem. 1998. PMID: 9857099

2

Synthesis and structure-activity relationship of fluoro analogues of 8-{2-[4-(4-methoxyphenyl)piperazin-1yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione as selective alpha(1d)-adrenergic receptor antagonists.

Konkel MJ, Wetzel JM, Cahir M, Craig DA, Noble SA, Gluchowski C. Konkel MJ, et al. Among authors: gluchowski c. J Med Chem. 2005 Apr 21;48(8):3076-9. doi: 10.1021/jm0491391. J Med Chem. 2005. PMID: 15828846

3

Design and synthesis of an alpha1a-adrenergic receptor subtype-selective antagonist from BE2254.

Chiu G, Gluchowski C, Forray C. Chiu G, et al. Among authors: gluchowski c. Chem Biol Drug Des. 2006 Jun;67(6):437-9. doi: 10.1111/j.1747-0285.2006.00398.x. Chem Biol Drug Des. 2006. PMID: 16882319

4

Discovery of alpha 1a-adrenergic receptor antagonists based on the L-type Ca2+ channel antagonist niguldipine.

Wetzel JM, Miao SW, Forray C, Borden LA, Branchek TA, Gluchowski C. Wetzel JM, et al. Among authors: gluchowski c. J Med Chem. 1995 May 12;38(10):1579-81. doi: 10.1021/jm00010a001. J Med Chem. 1995. PMID: 7752182 No abstract available.

5

Design, synthesis and evaluation of substituted triarylnipecotic acid derivatives as GABA uptake inhibitors: identification of a ligand with moderate affinity and selectivity for the cloned human GABA transporter GAT-3.

Dhar TG, Borden LA, Tyagarajan S, Smith KE, Branchek TA, Weinshank RL, Gluchowski C. Dhar TG, et al. Among authors: gluchowski c. J Med Chem. 1994 Jul 22;37(15):2334-42. doi: 10.1021/jm00041a012. J Med Chem. 1994. PMID: 8057281

6

Identification of a dihydropyridine as a potent alpha1a adrenoceptor-selective antagonist that inhibits phenylephrine-induced contraction of the human prostate.

Wong WC, Chiu G, Wetzel JM, Marzabadi MR, Nagarathnam D, Wang D, Fang J, Miao SW, Hong X, Forray C, Vaysse PJ, Branchek TA, Gluchowski C, Tang R, Lepor H. Wong WC, et al. Among authors: gluchowski c. J Med Chem. 1998 Jul 2;41(14):2643-50. doi: 10.1021/jm980077m. J Med Chem. 1998. PMID: 9651170

7

Characterization of specific binding of [125I]L-762,459, a selective alpha1A-adrenoceptor radioligand to rat and human tissues.

O'Malley SS, Chen TB, Francis BE, Gibson RE, Burns HD, DiSalvo J, Bayne ML, Wetzel JM, Nagarathnam D, Marzabadi M, Gluchowski C, Chang RS. O'Malley SS, et al. Among authors: gluchowski c. Eur J Pharmacol. 1998 May 8;348(2-3):287-95. doi: 10.1016/s0014-2999(98)00149-6. Eur J Pharmacol. 1998. PMID: 9652345

8

Design and synthesis of novel dihydropyridine alpha-1a antagonists.

Marzabadi MR, Hong X, Nagarathnam D, Miao SW, Chiu G, Wong WC, Wetzel JM, Fang J, Forray C, Chen TB, O'Malley SS, Chang RS, Gluchowski C. Marzabadi MR, et al. Among authors: gluchowski c. Bioorg Med Chem Lett. 1999 Oct 4;9(19):2843-8. doi: 10.1016/s0960-894x(99)00484-9. Bioorg Med Chem Lett. 1999. PMID: 10522703

9

Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 3. Approaches to eliminate opioid agonist metabolites by using substituted phenylpiperazine side chains.

Lagu B, Tian D, Nagarathnam D, Marzabadi MR, Wong WC, Miao SW, Zhang F, Sun W, Chiu G, Fang J, Forray C, Chang RS, Ransom RW, Chen TB, O'Malley S, Zhang K, Vyas KP, Gluchowski C. Lagu B, et al. Among authors: gluchowski c. J Med Chem. 1999 Nov 18;42(23):4794-803. doi: 10.1021/jm990202+. J Med Chem. 1999. PMID: 10579842

10

Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 4. Structure-activity relationship in the dihydropyrimidine series.

Wong WC, Sun W, Lagu B, Tian D, Marzabadi MR, Zhang F, Nagarathnam D, Miao SW, Wetzel JM, Peng J, Forray C, Chang RS, Chen TB, Ransom R, O'Malley S, Broten TP, Kling P, Vyas KP, Zhang K, Gluchowski C. Wong WC, et al. Among authors: gluchowski c. J Med Chem. 1999 Nov 18;42(23):4804-13. doi: 10.1021/jm9902032. J Med Chem. 1999. PMID: 10579843

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