Springer CJ - Search Results

1

Self-immolative nitrogen mustard prodrugs for suicide gene therapy.

Niculescu-Duvaz D, Niculescu-Duvaz I, Friedlos F, Martin J, Spooner R, Davies L, Marais R, Springer CJ. Niculescu-Duvaz D, et al. Among authors: springer cj. J Med Chem. 1998 Dec 17;41(26):5297-309. doi: 10.1021/jm980425k. J Med Chem. 1998. PMID: 9857097

2

Structure-activity relationship in cationic lipid mediated gene transfection.

Niculescu-Duvaz D, Heyes J, Springer CJ. Niculescu-Duvaz D, et al. Among authors: springer cj. Curr Med Chem. 2003 Jul;10(14):1233-61. doi: 10.2174/0929867033457476. Curr Med Chem. 2003. PMID: 12678797 Review.

3

Self-immolative nitrogen mustards prodrugs cleavable by carboxypeptidase G2 (CPG2) showing large cytotoxicity differentials in GDEPT.

Niculescu-Duvaz D, Niculescu-Duvaz I, Friedlos F, Martin J, Lehouritis P, Marais R, Springer CJ. Niculescu-Duvaz D, et al. Among authors: springer cj. J Med Chem. 2003 Apr 24;46(9):1690-705. doi: 10.1021/jm020462i. J Med Chem. 2003. PMID: 12699387

4

Gene regulation in cancer gene therapy strategies.

Scanlon I, Lehouritis P, Niculescu-Duvaz I, Marais R, Springer CJ. Scanlon I, et al. Among authors: springer cj. Curr Med Chem. 2003 Oct;10(20):2175-84. doi: 10.2174/0929867033456837. Curr Med Chem. 2003. PMID: 12871091 Review.

5

Design of prodrugs for suicide gene therapy.

Niculescu-Duvaz D, Niculescu-Duvaz I, Springer CJ. Niculescu-Duvaz D, et al. Among authors: springer cj. Methods Mol Med. 2004;90:161-202. doi: 10.1385/1-59259-429-8:161. Methods Mol Med. 2004. PMID: 14657564 Review. No abstract available.

6

Introduction to the background, principles, and state of the art in suicide gene therapy.

Niculescu-Duvaz I, Springer CJ. Niculescu-Duvaz I, et al. Among authors: springer cj. Mol Biotechnol. 2005 May;30(1):71-88. doi: 10.1385/MB:30:1:071. Mol Biotechnol. 2005. PMID: 15805578 Review.

7

Novel fluorinated prodrugs for activation by carboxypeptidase G2 showing good in vivo antitumor activity in gene-directed enzyme prodrug therapy.

Davies LC, Friedlos F, Hedley D, Martin J, Ogilvie LM, Scanlon IJ, Springer CJ. Davies LC, et al. Among authors: springer cj. J Med Chem. 2005 Aug 11;48(16):5321-8. doi: 10.1021/jm0502182. J Med Chem. 2005. PMID: 16078849

8

Novel inhibitors of B-RAF based on a disubstituted pyrazine scaffold. Generation of a nanomolar lead.

Niculescu-Duvaz I, Roman E, Whittaker SR, Friedlos F, Kirk R, Scanlon IJ, Davies LC, Niculescu-Duvaz D, Marais R, Springer CJ. Niculescu-Duvaz I, et al. Among authors: springer cj. J Med Chem. 2006 Jan 12;49(1):407-16. doi: 10.1021/jm050983g. J Med Chem. 2006. PMID: 16392826

9

Novel inhibitors of the v-raf murine sarcoma viral oncogene homologue B1 (BRAF) based on a 2,6-disubstituted pyrazine scaffold.

Niculescu-Duvaz I, Roman E, Whittaker SR, Friedlos F, Kirk R, Scanlon IJ, Davies LC, Niculescu-Duvaz D, Marais R, Springer CJ. Niculescu-Duvaz I, et al. Among authors: springer cj. J Med Chem. 2008 Jun 12;51(11):3261-74. doi: 10.1021/jm070776b. Epub 2008 May 13. J Med Chem. 2008. PMID: 18473434

10

Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy.

Friedlos F, Lehouritis P, Ogilvie L, Hedley D, Davies L, Bermudes D, King I, Martin J, Marais R, Springer CJ. Friedlos F, et al. Among authors: springer cj. Clin Cancer Res. 2008 Jul 1;14(13):4259-66. doi: 10.1158/1078-0432.CCR-07-4800. Clin Cancer Res. 2008. PMID: 18594008

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