Pope AJ - Search Results

1

Effects of substrate and inhibitor binding on proteolysis of isoleucyl-tRNA synthetase from Staphylococcus aureus.

Pope AJ, McVey M, Fantom K, Moore KJ. Pope AJ, et al. J Biol Chem. 1998 Nov 27;273(48):31702-6. doi: 10.1074/jbc.273.48.31702. J Biol Chem. 1998. PMID: 9822631 Free article.

2

Characterization of isoleucyl-tRNA synthetase from Staphylococcus aureus. II. Mechanism of inhibition by reaction intermediate and pseudomonic acid analogues studied using transient and steady-state kinetics.

Pope AJ, Moore KJ, McVey M, Mensah L, Benson N, Osbourne N, Broom N, Brown MJ, O'Hanlon P. Pope AJ, et al. J Biol Chem. 1998 Nov 27;273(48):31691-701. doi: 10.1074/jbc.273.48.31691. J Biol Chem. 1998. PMID: 9822630 Free article.

3

Characterization of isoleucyl-tRNA synthetase from Staphylococcus aureus. I: Kinetic mechanism of the substrate activation reaction studied by transient and steady-state techniques.

Pope AJ, Lapointe J, Mensah L, Benson N, Brown MJ, Moore KJ. Pope AJ, et al. J Biol Chem. 1998 Nov 27;273(48):31680-90. doi: 10.1074/jbc.273.48.31680. J Biol Chem. 1998. PMID: 9822629 Free article.

4

Lipopeptide substrates for SpsB, the Staphylococcus aureus type I signal peptidase: design, conformation and conversion to alpha-ketoamide inhibitors.

Bruton G, Huxley A, O'Hanlon P, Orlek B, Eggleston D, Humphries J, Readshaw S, West A, Ashman S, Brown M, Moore K, Pope A, O'Dwyer K, Wang L. Bruton G, et al. Eur J Med Chem. 2003 Apr;38(4):351-6. doi: 10.1016/s0223-5234(03)00040-0. Eur J Med Chem. 2003. PMID: 12750021

5

Monitoring receptor oligomerization using time-resolved fluorescence resonance energy transfer and bioluminescence resonance energy transfer. The human delta -opioid receptor displays constitutive oligomerization at the cell surface, which is not regulated by receptor occupancy.

McVey M, Ramsay D, Kellett E, Rees S, Wilson S, Pope AJ, Milligan G. McVey M, et al. Among authors: pope aj. J Biol Chem. 2001 Apr 27;276(17):14092-9. doi: 10.1074/jbc.M008902200. Epub 2001 Jan 22. J Biol Chem. 2001. PMID: 11278447 Free article.

6

Single-molecule detection technologies in miniaturized high throughput screening: binding assays for g protein-coupled receptors using fluorescence intensity distribution analysis and fluorescence anisotropy.

Rüdiger M, Haupts U, Moore KJ, Pope AJ. Rüdiger M, et al. Among authors: pope aj. J Biomol Screen. 2001 Feb;6(1):29-37. doi: 10.1177/108705710100600105. J Biomol Screen. 2001. PMID: 11679163

7

Real experiences of uHTS: a prototypic 1536-well fluorescence anisotropy-based uHTS screen and application of well-level quality control procedures.

Turconi S, Shea K, Ashman S, Fantom K, Earnshaw DL, Bingham RP, Haupts UM, Brown MJ, Pope AJ. Turconi S, et al. Among authors: pope aj. J Biomol Screen. 2001 Oct;6(5):275-90. doi: 10.1177/108705710100600502. J Biomol Screen. 2001. PMID: 11689128

8

Interaction of tyrosyl aryl dipeptides with S. aureus tyrosyl tRNA synthetase: inhibition and crystal structure of a complex.

Jarvest RL, Berge JM, Houge-Frydrych CS, Janson C, Mensah LM, O'Hanlon PJ, Pope A, Saldanha A, Qiu X. Jarvest RL, et al. Bioorg Med Chem Lett. 1999 Oct 4;9(19):2859-62. doi: 10.1016/s0960-894x(99)00488-6. Bioorg Med Chem Lett. 1999. PMID: 10522706

9

Effect of potent urease inhibitor, fluorofamide, on Helicobacter sp. in vivo and in vitro.

Pope AJ, Toseland CD, Rushant B, Richardson S, McVey M, Hills J. Pope AJ, et al. Dig Dis Sci. 1998 Jan;43(1):109-19. doi: 10.1023/a:1018884322973. Dig Dis Sci. 1998. PMID: 9508511

10

Rational design of femtomolar inhibitors of isoleucyl tRNA synthetase from a binding model for pseudomonic acid-A.

Brown MJ, Mensah LM, Doyle ML, Broom NJ, Osbourne N, Forrest AK, Richardson CM, O'Hanlon PJ, Pope AJ. Brown MJ, et al. Among authors: pope aj. Biochemistry. 2000 May 23;39(20):6003-11. doi: 10.1021/bi000148v. Biochemistry. 2000. PMID: 10821672

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