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High TCR diversity ensures optimal function and homeostasis of Foxp3+ regulatory T cells.
Föhse L, Suffner J, Suhre K, Wahl B, Lindner C, Lee CW, Schmitz S, Haas JD, Lamprecht S, Koenecke C, Bleich A, Hämmerling GJ, Malissen B, Suerbaum S, Förster R, Prinz I. Föhse L, et al. Among authors: suffner j. Eur J Immunol. 2011 Nov;41(11):3101-13. doi: 10.1002/eji.201141986. Epub 2011 Oct 18. Eur J Immunol. 2011. PMID: 21932448 Free article.
Myelin-reactive, TGF-β-induced regulatory T cells can be programmed to develop Th1-like effector function but remain less proinflammatory than myelin-reactive Th1 effectors and can suppress pathogenic T cell clonal expansion in vivo.
O'Connor RA, Leech MD, Suffner J, Hämmerling GJ, Anderton SM. O'Connor RA, et al. Among authors: suffner j. J Immunol. 2010 Dec 15;185(12):7235-43. doi: 10.4049/jimmunol.1001551. Epub 2010 Nov 17. J Immunol. 2010. PMID: 21084662