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Preparation of highly potent and selective non-peptide antagonists of the arginine vasopressin V1A receptor by introduction of a 2-ethyl-1H-1-imidazolyl group.
Shimada Y, Akane H, Taniguchi N, Matsuhisa A, Kawano N, Kikuchi K, Yatsu T, Tahara A, Tomura Y, Kusayama T, Wada K, Tsukada J, Tsunoda T, Tanaka A. Shimada Y, et al. Among authors: matsuhisa a. Chem Pharm Bull (Tokyo). 2005 Jul;53(7):764-9. doi: 10.1248/cpb.53.764. Chem Pharm Bull (Tokyo). 2005. PMID: 15997131 Free article.
Synthesis and biological activity of novel 4,4-difluorobenzazepine derivatives as non-peptide antagonists of the arginine vasopressin V1A receptor.
Shimada Y, Taniguchi N, Matsuhisa A, Akane H, Kawano N, Suzuki T, Tobe T, Kakefuda A, Yatsu T, Tahara A, Tomura Y, Kusayama T, Wada K, Tsukada J, Orita M, Tsunoda T, Tanaka A. Shimada Y, et al. Among authors: matsuhisa a. Bioorg Med Chem. 2006 Mar 15;14(6):1827-37. doi: 10.1016/j.bmc.2005.10.035. Epub 2005 Nov 11. Bioorg Med Chem. 2006. PMID: 16290163
Nonpeptide arginine vasopressin antagonists for both V1A and V2 receptors: synthesis and pharmacological properties of 4'-[5-(substituted methylidene)-2,3,4,5-tetrahydro-1H-1-ben zoazepine-1-carbonyl]benzanilide and 4'-[5-(substituted methyl)-2,3-dihydro-1H-1-benzoazepine-1- carbonyl]benzanilide derivatives.
Matsuhisa A, Kikuchi K, Sakamoto K, Yatsu T, Tanaka A. Matsuhisa A, et al. Chem Pharm Bull (Tokyo). 1999 Mar;47(3):329-39. doi: 10.1248/cpb.47.329. Chem Pharm Bull (Tokyo). 1999. PMID: 10212383
Nonpeptide arginine vasopressin antagonists for both V1A and V2 receptors: synthesis and pharmacological properties of 4-(1,4,5,6-tetrahydroimidazo[4,5-d][1]benzoazepine-6-carbonyl)benzanili de derivatives and 4'-(5,6-dihydro-4H-thiazolo[5,4-d][1]benzoazepine-6-carbonyl)benzanilid e derivatives.
Matsuhisa A, Taniguchi N, Koshio H, Yatsu T, Tanaka A. Matsuhisa A, et al. Chem Pharm Bull (Tokyo). 2000 Jan;48(1):21-31. doi: 10.1248/cpb.48.21. Chem Pharm Bull (Tokyo). 2000. PMID: 10705470
Highly potent and orally active non-peptide arginine vasopressin antagonists for both V1A and V2 receptors: synthesis and pharmacological properties of 4'-[(4,4-difluoro-5-methylidene-2,3,4,5-tetrahydro-1H-1-benzoazepin-1-y l)carbonyl]-2-phenylbenzanilide derivatives.
Shimada Y, Taniguchi N, Matsuhisa A, Sakamoto K, Yatsu T, Tanaka A. Shimada Y, et al. Among authors: matsuhisa a. Chem Pharm Bull (Tokyo). 2000 Nov;48(11):1644-51. doi: 10.1248/cpb.48.1644. Chem Pharm Bull (Tokyo). 2000. PMID: 11086891
60 results