Cook JM - Search Results

1

Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines at five recombinant GABAA/benzodiazepine receptor subtypes [alphaxbeta3gamma2 (x = 1-3, 5, and 6)] via comparative molecular field analysis.

Huang Q, Liu R, Zhang P, He X, McKernan R, Gan T, Bennett DW, Cook JM. Huang Q, et al. Among authors: cook jm. J Med Chem. 1998 Oct 8;41(21):4130-42. doi: 10.1021/jm980317y. J Med Chem. 1998. PMID: 9767648

2

Synthesis of novel 2-phenyl-2H-pyrazolo[4,3-c]isoquinolin-3-ols: topological comparisons with analogues of 2-phenyl-2,5-dihydropyrazolo[4,3-c]quinolin-3(3H)-ones at benzodiazepine receptors.

Allen MS, Skolnick P, Cook JM. Allen MS, et al. Among authors: cook jm. J Med Chem. 1992 Jan 24;35(2):368-74. doi: 10.1021/jm00080a024. J Med Chem. 1992. PMID: 1310121

3

Predictive binding of beta-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach.

Allen MS, LaLoggia AJ, Dorn LJ, Martin MJ, Costantino G, Hagen TJ, Koehler KF, Skolnick P, Cook JM. Allen MS, et al. Among authors: cook jm. J Med Chem. 1992 Oct 30;35(22):4001-10. doi: 10.1021/jm00100a004. J Med Chem. 1992. PMID: 1331452

4

Synthetic and computer assisted analysis of the pharmacophore for agonists at benzodiazepine receptors.

Diaz-Arauzo H, Koehler KF, Hagen TJ, Cook JM. Diaz-Arauzo H, et al. Among authors: cook jm. Life Sci. 1991;49(3):207-16. doi: 10.1016/0024-3205(91)90005-v. Life Sci. 1991. PMID: 1648158

5

Inverse agonists, probes to study the structure, topology and function of the benzodiazepine receptor.

Cook JM, Diaz-Arauzo H, Allen MS. Cook JM, et al. NIDA Res Monogr. 1990;105:133-9. NIDA Res Monogr. 1990. PMID: 1652068 Review. No abstract available.

6

The agonist pharmacophore of the benzodiazepine receptor. Synthesis of a selective anticonvulsant/anxiolytic.

Diaz-Arauzo H, Evoniuk GE, Skolnick P, Cook JM. Diaz-Arauzo H, et al. Among authors: cook jm. J Med Chem. 1991 May;34(5):1754-6. doi: 10.1021/jm00109a035. J Med Chem. 1991. PMID: 1674542 No abstract available.

7

Structural requirements for agonist actions at the benzodiazepine receptor: studies with analogues of 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester.

Hollinshead SP, Trudell ML, Skolnick P, Cook JM. Hollinshead SP, et al. Among authors: cook jm. J Med Chem. 1990 Mar;33(3):1062-9. doi: 10.1021/jm00165a028. J Med Chem. 1990. PMID: 1968513

8

Synthesis of substituted 7,12-dihydropyrido[3,2-b:5,4-b']diindoles: rigid planar benzodiazepine receptor ligands with inverse agonist/antagonist properties.

Trudell ML, Lifer SL, Tan YC, Martin MJ, Deng L, Skolnick P, Cook JM. Trudell ML, et al. Among authors: cook jm. J Med Chem. 1990 Sep;33(9):2412-20. doi: 10.1021/jm00171a015. J Med Chem. 1990. PMID: 2167978

9

Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore.

Allen MS, Hagen TJ, Trudell ML, Codding PW, Skolnick P, Cook JM. Allen MS, et al. Among authors: cook jm. J Med Chem. 1988 Sep;31(9):1854-61. doi: 10.1021/jm00117a029. J Med Chem. 1988. PMID: 2842507

10

Biomimetic approach to potential benzodiazepine receptor agonists and antagonists.

Guzman F, Cain M, Larscheid P, Hagen T, Cook JM, Schweri M, Skolnick P, Paul SM. Guzman F, et al. Among authors: cook jm. J Med Chem. 1984 May;27(5):564-70. doi: 10.1021/jm00371a002. J Med Chem. 1984. PMID: 6325688

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