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Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.
Song Y, Connor DT, Doubleday R, Sorenson RJ, Sercel AD, Unangst PC, Roth BD, Gilbertsen RB, Chan K, Schrier DJ, Guglietta A, Bornemeier DA, Dyer RD. Song Y, et al. J Med Chem. 1999 Apr 8;42(7):1151-60. doi: 10.1021/jm9805081. J Med Chem. 1999. PMID: 10197959
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.
Song Y, Connor DT, Sercel AD, Sorenson RJ, Doubleday R, Unangst PC, Roth BD, Beylin VG, Gilbertsen RB, Chan K, Schrier DJ, Guglietta A, Bornemeier DA, Dyer RD. Song Y, et al. J Med Chem. 1999 Apr 8;42(7):1161-9. doi: 10.1021/jm980570y. J Med Chem. 1999. PMID: 10197960
Bacterial two-component signalling as a therapeutic target in drug design. Inhibition of NRII by the diphenolic methanes (bisphenols).
Domagala JM, Alessi D, Cummings M, Gracheck S, Huang L, Huband M, Johnson G, Olson E, Shapiro M, Singh R, Song Y, Van Bogelen R, Vo D, Wold S. Domagala JM, et al. Among authors: song y. Adv Exp Med Biol. 1998;456:269-86. doi: 10.1007/978-1-4615-4897-3_14. Adv Exp Med Biol. 1998. PMID: 10549373 Review. No abstract available.
The human immunodeficiency virus type 1 (HIV-1) nucleocapsid protein zinc ejection activity of disulfide benzamides and benzisothiazolones: correlation with anti-HIV and virucidal activities.
Tummino PJ, Harvey PJ, McQuade T, Domagala J, Gogliotti R, Sanchez J, Song Y, Hupe D. Tummino PJ, et al. Among authors: song y. Antimicrob Agents Chemother. 1997 Feb;41(2):394-400. doi: 10.1128/AAC.41.2.394. Antimicrob Agents Chemother. 1997. PMID: 9021197 Free PMC article.
N,N-dialkyl-dipeptidylamines as novel N-type calcium channel blockers.
Hu LY, Ryder TR, Rafferty MF, Cody WL, Lotarski SM, Miljanich GP, Millerman E, Rock DM, Song Y, Stoehr SJ, Taylor CP, Weber ML, Szoke BG, Vartanian MG. Hu LY, et al. Among authors: song y. Bioorg Med Chem Lett. 1999 Mar 22;9(6):907-12. doi: 10.1016/s0960-894x(99)00100-6. Bioorg Med Chem Lett. 1999. PMID: 10206559
(S)-4-Methyl-2-(methylamino)pentanoic acid [4, 4-bis(4-fluorophenyl)butyl]amide hydrochloride, a novel calcium channel antagonist, is efficacious in several animal models of pain.
Song Y, Bowersox SS, Connor DT, Dooley DJ, Lotarski SM, Malone T, Miljanich G, Millerman E, Rafferty MF, Rock D, Roth BD, Schmidt J, Stoehr S, Szoke BG, Taylor C, Vartanian M, Wang YX. Song Y, et al. J Med Chem. 2000 Sep 21;43(19):3474-7. doi: 10.1021/jm000134n. J Med Chem. 2000. PMID: 11000000 No abstract available.
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