Leeson PD - Search Results

1

3-(1-piperazinyl)-4,5-dihydro-1H-benzo[g]indazoles: high affinity ligands for the human dopamine D4 receptor with improved selectivity over ion channels.

Collins I, Rowley M, Davey WB, Emms F, Marwood R, Patel S, Patel S, Fletcher A, Ragan IC, Leeson PD, Scott AL, Broten T. Collins I, et al. Among authors: leeson pd. Bioorg Med Chem. 1998 Jun;6(6):743-53. doi: 10.1016/s0968-0896(98)00028-5. Bioorg Med Chem. 1998. PMID: 9681140

2

2-Carboxytetrahydroquinolines. Conformational and stereochemical requirements for antagonism of the glycine site on the NMDA receptor.

Carling RW, Leeson PD, Moseley AM, Baker R, Foster AC, Grimwood S, Kemp JA, Marshall GR. Carling RW, et al. Among authors: leeson pd. J Med Chem. 1992 May 29;35(11):1942-53. doi: 10.1021/jm00089a003. J Med Chem. 1992. PMID: 1534583

3

4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor.

Leeson PD, Carling RW, Moore KW, Moseley AM, Smith JD, Stevenson G, Chan T, Baker R, Foster AC, Grimwood S, et al. Leeson PD, et al. J Med Chem. 1992 May 29;35(11):1954-68. doi: 10.1021/jm00089a004. J Med Chem. 1992. PMID: 1534584

4

Role of hydrogen bonding in ligand interaction with the N-methyl-D-aspartate receptor ion channel.

Leeson PD, Carling RW, James K, Smith JD, Moore KW, Wong EH, Baker R. Leeson PD, et al. J Med Chem. 1990 May;33(5):1296-305. doi: 10.1021/jm00167a005. J Med Chem. 1990. PMID: 1691788

5

Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor.

Leeson PD, Baker R, Carling RW, Curtis NR, Moore KW, Williams BJ, Foster AC, Donald AE, Kemp JA, Marshall GR. Leeson PD, et al. J Med Chem. 1991 Apr;34(4):1243-52. doi: 10.1021/jm00108a002. J Med Chem. 1991. PMID: 1826744

6

Allosteric modulation of the glutamate site on the NMDA receptor by four novel glycine site antagonists.

Grimwood S, Kulagowski JJ, Mawer IM, Rowley M, Leeson PD, Foster AC. Grimwood S, et al. Among authors: leeson pd. Eur J Pharmacol. 1995 Aug 15;290(3):221-6. doi: 10.1016/0922-4106(95)00081-x. Eur J Pharmacol. 1995. PMID: 7589216

7

The anticonvulsant and behavioural profile of L-687,414, a partial agonist acting at the glycine modulatory site on the N-methyl-D-aspartate (NMDA) receptor complex.

Tricklebank MD, Bristow LJ, Hutson PH, Leeson PD, Rowley M, Saywell K, Singh L, Tattersall FD, Thorn L, Williams BJ. Tricklebank MD, et al. Among authors: leeson pd. Br J Pharmacol. 1994 Nov;113(3):729-36. doi: 10.1111/j.1476-5381.1994.tb17054.x. Br J Pharmacol. 1994. PMID: 7858861 Free PMC article.

8

The glycine site on the NMDA receptor: structure-activity relationships and therapeutic potential.

Leeson PD, Iversen LL. Leeson PD, et al. J Med Chem. 1994 Nov 25;37(24):4053-67. doi: 10.1021/jm00050a001. J Med Chem. 1994. PMID: 7990104 Review. No abstract available.

9

3'-(Arylmethyl)- and 3'-(aryloxy)-3-phenyl-4-hydroxyquinolin-2(1H)-ones: orally active antagonists of the glycine site on the NMDA receptor.

Kulagowski JJ, Baker R, Curtis NR, Leeson PD, Mawer IM, Moseley AM, Ridgill MP, Rowley M, Stansfield I, Foster AC, et al. Kulagowski JJ, et al. Among authors: leeson pd. J Med Chem. 1994 May 13;37(10):1402-5. doi: 10.1021/jm00036a002. J Med Chem. 1994. PMID: 8182696 No abstract available.

10

3-Acyl-4-hydroxyquinolin-2(1H)-ones. Systemically active anticonvulsants acting by antagonism at the glycine site of the N-methyl-D-aspartate receptor complex.

Rowley M, Leeson PD, Stevenson GI, Moseley AM, Stansfield I, Sanderson I, Robinson L, Baker R, Kemp JA, Marshall GR, et al. Rowley M, et al. Among authors: leeson pd. J Med Chem. 1993 Oct 29;36(22):3386-96. doi: 10.1021/jm00074a020. J Med Chem. 1993. PMID: 8230129

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