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A hypermutable insert in an immunoglobulin transgene contains hotspots of somatic mutation and sequences predicting highly stable structures in the RNA transcript.
Storb U, Klotz EL, Hackett J Jr, Kage K, Bozek G, Martin TE. Storb U, et al. J Exp Med. 1998 Aug 17;188(4):689-98. doi: 10.1084/jem.188.4.689. J Exp Med. 1998. PMID: 9705951 Free PMC article.
The mutation mechanism had previously been shown to depend upon transcription initiation, suggesting that a mutator factor was loaded on an RNA polymerase initiating at the promoter and causing mutations during elongation (Peters, A., and U. Storb. 1996. Immunity. 4 …
The mutation mechanism had previously been shown to depend upon transcription initiation, suggesting that a mutator factor was loaded on an …
Analysis of somatic mutations in kappa transgenes.
Hackett J Jr, Rogerson BJ, O'Brien RL, Storb U. Hackett J Jr, et al. Among authors: storb u. J Exp Med. 1990 Jul 1;172(1):131-7. doi: 10.1084/jem.172.1.131. J Exp Med. 1990. PMID: 2358776 Free PMC article.
156 results