Roach AG - Search Results

1

Selective endothelin A receptor antagonists. 4. Discovery and structure-activity relationships of stilbene acid and alcohol derivatives.

Astles PC, Brown TJ, Halley F, Handscombe CM, Harris NV, McCarthy C, McLay IM, Lockey P, Majid T, Porter B, Roach AG, Smith C, Walsh R. Astles PC, et al. Among authors: roach ag. J Med Chem. 1998 Jul 16;41(15):2745-53. doi: 10.1021/jm970847e. J Med Chem. 1998. PMID: 9667965

2

Selective endothelin A receptor antagonists. 3. Discovery and structure-activity relationships of a series of 4-phenoxybutanoic acid derivatives.

Astles PC, Brealey C, Brown TJ, Facchini V, Handscombe C, Harris NV, McCarthy C, McLay IM, Porter B, Roach AG, Sargent C, Smith C, Walsh RJ. Astles PC, et al. Among authors: roach ag. J Med Chem. 1998 Jul 16;41(15):2732-44. doi: 10.1021/jm9707131. J Med Chem. 1998. PMID: 9667964

3

Selective ET(A) antagonists. 5. Discovery and structure-activity relationships of phenoxyphenylacetic acid derivatives.

Astles PC, Brown TJ, Halley F, Handscombe CM, Harris NV, Majid TN, McCarthy C, McLay IM, Morley A, Porter B, Roach AG, Sargent C, Smith C, Walsh RJ. Astles PC, et al. Among authors: roach ag. J Med Chem. 2000 Mar 9;43(5):900-10. doi: 10.1021/jm990378b. J Med Chem. 2000. PMID: 10715156

4

New low-density lipoprotein receptor upregulators acting via a novel mechanism.

Ashton MJ, Brown TJ, Fenton G, Halley F, Harper MF, Lockey PM, Porter B, Roach AG, Stuttle KA, Vicker N, Walsh RJ. Ashton MJ, et al. Among authors: roach ag. J Med Chem. 1996 Aug 16;39(17):3343-56. doi: 10.1021/jm960153q. J Med Chem. 1996. PMID: 8765518

5

Structure-activity relationships of a novel series of melanin-concentrating hormone (MCH) receptor antagonists.

Arienzo R, Clark DE, Cramp S, Daly S, Dyke HJ, Lockey P, Norman D, Roach AG, Stuttle K, Tomlinson M, Wong M, Wren SP. Arienzo R, et al. Among authors: roach ag. Bioorg Med Chem Lett. 2004 Aug 2;14(15):4099-102. doi: 10.1016/j.bmcl.2004.05.051. Bioorg Med Chem Lett. 2004. PMID: 15225734

6

A virtual screening approach to finding novel and potent antagonists at the melanin-concentrating hormone 1 receptor.

Clark DE, Higgs C, Wren SP, Dyke HJ, Wong M, Norman D, Lockey PM, Roach AG. Clark DE, et al. Among authors: roach ag. J Med Chem. 2004 Jul 29;47(16):3962-71. doi: 10.1021/jm040762v. J Med Chem. 2004. PMID: 15267235

7

Effect of endothelin antagonists with or without BQ 788 on ET-1 responses in pithed rats.

Sargent CA, Brazdil R, Flynn DA, Brown TJ, Roach AG. Sargent CA, et al. Among authors: roach ag. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S216-8. J Cardiovasc Pharmacol. 1995. PMID: 8587367

8

Sarafotoxin S6c elicits a non-ETA or non-ETB-mediated pressor response in the pithed rat.

Flynn DA, Sargent CA, Brazdil R, Brown TJ, Roach AG. Flynn DA, et al. Among authors: roach ag. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S219-21. J Cardiovasc Pharmacol. 1995. PMID: 8587368

9

Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.

Price S, Bordogna W, Braganza R, Bull RJ, Dyke HJ, Gardan S, Gill M, Harris NV, Heald RA, van den Heuvel M, Lockey PM, Lloyd J, Molina AG, Roach AG, Roussel F, Sutton JM, White AB. Price S, et al. Among authors: roach ag. Bioorg Med Chem Lett. 2007 Jan 15;17(2):363-9. doi: 10.1016/j.bmcl.2006.10.045. Epub 2006 Oct 24. Bioorg Med Chem Lett. 2007. PMID: 17107790

10

Quinazoline and benzimidazole MCH-1R antagonists.

Arienzo R, Cramp S, Dyke HJ, Lockey PM, Norman D, Roach AG, Smith P, Wong M, Wren SP. Arienzo R, et al. Among authors: roach ag. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1403-7. doi: 10.1016/j.bmcl.2006.11.092. Epub 2006 Dec 2. Bioorg Med Chem Lett. 2007. PMID: 17178222

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