Harris NV - Search Results

1

Selective endothelin A receptor antagonists. 4. Discovery and structure-activity relationships of stilbene acid and alcohol derivatives.

Astles PC, Brown TJ, Halley F, Handscombe CM, Harris NV, McCarthy C, McLay IM, Lockey P, Majid T, Porter B, Roach AG, Smith C, Walsh R. Astles PC, et al. Among authors: harris nv. J Med Chem. 1998 Jul 16;41(15):2745-53. doi: 10.1021/jm970847e. J Med Chem. 1998. PMID: 9667965

2

Acyl-CoA:Cholesterol O-acyltransferase (ACAT) inhibitors. 2. 2-(1,3-Dioxan-2-yl)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT.

Astles PC, Ashton MJ, Bridge AW, Harris NV, Hart TW, Parrott DP, Porter B, Riddell D, Smith C, Williams RJ. Astles PC, et al. Among authors: harris nv. J Med Chem. 1996 Mar 29;39(7):1423-32. doi: 10.1021/jm9505876. J Med Chem. 1996. PMID: 8691472

3

Selective endothelin A receptor antagonists. 3. Discovery and structure-activity relationships of a series of 4-phenoxybutanoic acid derivatives.

Astles PC, Brealey C, Brown TJ, Facchini V, Handscombe C, Harris NV, McCarthy C, McLay IM, Porter B, Roach AG, Sargent C, Smith C, Walsh RJ. Astles PC, et al. Among authors: harris nv. J Med Chem. 1998 Jul 16;41(15):2732-44. doi: 10.1021/jm9707131. J Med Chem. 1998. PMID: 9667964

4

Selective ET(A) antagonists. 5. Discovery and structure-activity relationships of phenoxyphenylacetic acid derivatives.

Astles PC, Brown TJ, Halley F, Handscombe CM, Harris NV, Majid TN, McCarthy C, McLay IM, Morley A, Porter B, Roach AG, Sargent C, Smith C, Walsh RJ. Astles PC, et al. Among authors: harris nv. J Med Chem. 2000 Mar 9;43(5):900-10. doi: 10.1021/jm990378b. J Med Chem. 2000. PMID: 10715156

5

Diamine containing VLA-4 antagonists.

Astles PC, Harris NV, Morley AD. Astles PC, et al. Among authors: harris nv. Bioorg Med Chem. 2001 Aug;9(8):2195-202. doi: 10.1016/s0968-0896(01)00132-8. Bioorg Med Chem. 2001. PMID: 11504657

6

Acyl-CoA:cholesterol O-acyl transferase (ACAT) inhibitors. 1. 2-(Alkylthio)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT.

Harris NV, Smith C, Ashton MJ, Bridge AW, Bush RC, Coffee EC, Dron DI, Harper MF, Lythgoe DJ, Newton CG, et al. Harris NV, et al. J Med Chem. 1992 Nov 13;35(23):4384-92. doi: 10.1021/jm00101a016. J Med Chem. 1992. PMID: 1447739

7

Antifolate and antibacterial activities of 5-substituted 2,4-diaminoquinazolines.

Harris NV, Smith C, Bowden K. Harris NV, et al. J Med Chem. 1990 Jan;33(1):434-44. doi: 10.1021/jm00163a067. J Med Chem. 1990. PMID: 2404122

8

Identification and optimisation of a series of substituted 5-(1H-pyrazol-3-yl)-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.

Price S, Bordogna W, Bull RJ, Clark DE, Crackett PH, Dyke HJ, Gill M, Harris NV, Gorski J, Lloyd J, Lockey PM, Mullett J, Roach AG, Roussel F, White AB. Price S, et al. Among authors: harris nv. Bioorg Med Chem Lett. 2007 Jan 15;17(2):370-5. doi: 10.1016/j.bmcl.2006.10.048. Epub 2006 Oct 24. Bioorg Med Chem Lett. 2007. PMID: 17095213

9

Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.

Price S, Bordogna W, Braganza R, Bull RJ, Dyke HJ, Gardan S, Gill M, Harris NV, Heald RA, van den Heuvel M, Lockey PM, Lloyd J, Molina AG, Roach AG, Roussel F, Sutton JM, White AB. Price S, et al. Among authors: harris nv. Bioorg Med Chem Lett. 2007 Jan 15;17(2):363-9. doi: 10.1016/j.bmcl.2006.10.045. Epub 2006 Oct 24. Bioorg Med Chem Lett. 2007. PMID: 17107790

10

Hypolipidaemic properties of a potent and bioavailable alkylsulphinyl-diphenylimidazole ACAT inhibitor (RP 73163) in animals fed diets low in cholesterol.

Riddell D, Bright CP, Burton BJ, Bush RC, Harris NV, Hele D, Moore UM, Naik K, Parrott DP, Smith C, Williams RJ. Riddell D, et al. Among authors: harris nv. Biochem Pharmacol. 1996 Oct 25;52(8):1177-86. doi: 10.1016/0006-2952(96)00455-8. Biochem Pharmacol. 1996. PMID: 8937424

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