Sargent C - Search Results

1

Selective endothelin A receptor antagonists. 3. Discovery and structure-activity relationships of a series of 4-phenoxybutanoic acid derivatives.

Astles PC, Brealey C, Brown TJ, Facchini V, Handscombe C, Harris NV, McCarthy C, McLay IM, Porter B, Roach AG, Sargent C, Smith C, Walsh RJ. Astles PC, et al. Among authors: sargent c. J Med Chem. 1998 Jul 16;41(15):2732-44. doi: 10.1021/jm9707131. J Med Chem. 1998. PMID: 9667964

2

Selective ET(A) antagonists. 5. Discovery and structure-activity relationships of phenoxyphenylacetic acid derivatives.

Astles PC, Brown TJ, Halley F, Handscombe CM, Harris NV, Majid TN, McCarthy C, McLay IM, Morley A, Porter B, Roach AG, Sargent C, Smith C, Walsh RJ. Astles PC, et al. Among authors: sargent c. J Med Chem. 2000 Mar 9;43(5):900-10. doi: 10.1021/jm990378b. J Med Chem. 2000. PMID: 10715156

3

Effect of endothelin antagonists with or without BQ 788 on ET-1 responses in pithed rats.

Sargent CA, Brazdil R, Flynn DA, Brown TJ, Roach AG. Sargent CA, et al. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S216-8. J Cardiovasc Pharmacol. 1995. PMID: 8587367

4

Sarafotoxin S6c elicits a non-ETA or non-ETB-mediated pressor response in the pithed rat.

Flynn DA, Sargent CA, Brazdil R, Brown TJ, Roach AG. Flynn DA, et al. Among authors: sargent ca. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S219-21. J Cardiovasc Pharmacol. 1995. PMID: 8587368

5

Effects of cyclosporin A administered into the airways against antigen-induced airway inflammation and hyperreactivity in the rat.

Underwood SL, McMillan S, Reeves R, Hunt J, Brealey CJ, Webber S, Foster M, Sargent CA. Underwood SL, et al. Among authors: sargent ca. Eur J Pharmacol. 2001 May 25;420(2-3):165-73. doi: 10.1016/s0014-2999(01)00975-x. Eur J Pharmacol. 2001. PMID: 11408039

6

Zwitterionic CRTh2 antagonists.

Luker T, Bonnert R, Paine SW, Schmidt J, Sargent C, Cook AR, Cook A, Gardiner P, Hill S, Weyman-Jones C, Patel A, Thom S, Thorne P. Luker T, et al. Among authors: sargent c. J Med Chem. 2011 Mar 24;54(6):1779-88. doi: 10.1021/jm1014549. Epub 2011 Feb 28. J Med Chem. 2011. PMID: 21355602

7

Switching between agonists and antagonists at CRTh2 in a series of highly potent and selective biaryl phenoxyacetic acids.

Luker T, Bonnert R, Schmidt J, Sargent C, Paine SW, Thom S, Pairaudeau G, Patel A, Mohammed R, Akam E, Dougall I, Davis AM, Abbott P, Brough S, Millichip I, McInally T. Luker T, et al. Among authors: sargent c. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3616-21. doi: 10.1016/j.bmcl.2011.04.101. Epub 2011 Apr 28. Bioorg Med Chem Lett. 2011. PMID: 21592791

8

Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981.

Luker T, Bonnert R, Brough S, Cook AR, Dickinson MR, Dougall I, Logan C, Mohammed RT, Paine S, Sanganee HJ, Sargent C, Schmidt JA, Teague S, Thom S. Luker T, et al. Among authors: sargent c. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6288-92. doi: 10.1016/j.bmcl.2011.08.124. Epub 2011 Sep 5. Bioorg Med Chem Lett. 2011. PMID: 21944852

9

Effect of the p38 kinase inhibitor, SB 203580, on allergic airway inflammation in the rat.

Escott KJ, Belvisi MG, Birrell MA, Webber SE, Foster ML, Sargent CA. Escott KJ, et al. Among authors: sargent ca. Br J Pharmacol. 2000 Sep;131(2):173-6. doi: 10.1038/sj.bjp.0703605. Br J Pharmacol. 2000. PMID: 10991908 Free PMC article.

10

Immunosuppressive and anti-inflammatory effects of cyclic AMP phosphodiesterase (PDE) type 4 inhibitors.

Souness JE, Aldous D, Sargent C. Souness JE, et al. Among authors: sargent c. Immunopharmacology. 2000 May;47(2-3):127-62. doi: 10.1016/s0162-3109(00)00185-5. Immunopharmacology. 2000. PMID: 10878287 Review. No abstract available.

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