Przedborski S - Search Results

1

Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

Ara J, Przedborski S, Naini AB, Jackson-Lewis V, Trifiletti RR, Horwitz J, Ischiropoulos H. Ara J, et al. Among authors: przedborski s. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7659-63. doi: 10.1073/pnas.95.13.7659. Proc Natl Acad Sci U S A. 1998. PMID: 9636206 Free PMC article.

2

Nitration and inactivation of tyrosine hydroxylase by peroxynitrite.

Blanchard-Fillion B, Souza JM, Friel T, Jiang GC, Vrana K, Sharov V, Barrón L, Schöneich C, Quijano C, Alvarez B, Radi R, Przedborski S, Fernando GS, Horwitz J, Ischiropoulos H. Blanchard-Fillion B, et al. Among authors: przedborski s. J Biol Chem. 2001 Dec 7;276(49):46017-23. doi: 10.1074/jbc.M105564200. Epub 2001 Oct 5. J Biol Chem. 2001. PMID: 11590168 Free article.

The temporal association of tyrosine nitration with inactivation of TH activity in vitro suggests that this covalent post-translational modification is responsible for the in vivo loss of TH function (Ara, J., Przedborski, S., Naini, A. B., Jackson-Lewis, V., Trifil …

The temporal association of tyrosine nitration with inactivation of TH activity in vitro suggests that this covalent post-translational modi …

3

Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration.

Teismann P, Tieu K, Choi DK, Wu DC, Naini A, Hunot S, Vila M, Jackson-Lewis V, Przedborski S. Teismann P, et al. Among authors: przedborski s. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5473-8. doi: 10.1073/pnas.0837397100. Epub 2003 Apr 17. Proc Natl Acad Sci U S A. 2003. PMID: 12702778 Free PMC article.

4

NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.

Wu DC, Teismann P, Tieu K, Vila M, Jackson-Lewis V, Ischiropoulos H, Przedborski S. Wu DC, et al. Among authors: przedborski s. Proc Natl Acad Sci U S A. 2003 May 13;100(10):6145-50. doi: 10.1073/pnas.0937239100. Epub 2003 Apr 29. Proc Natl Acad Sci U S A. 2003. PMID: 12721370 Free PMC article.

5

Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity.

Przedborski S, Jackson-Lewis V, Yokoyama R, Shibata T, Dawson VL, Dawson TM. Przedborski S, et al. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4565-71. doi: 10.1073/pnas.93.10.4565. Proc Natl Acad Sci U S A. 1996. PMID: 8643444 Free PMC article.

6

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism.

Mandir AS, Przedborski S, Jackson-Lewis V, Wang ZQ, Simbulan-Rosenthal CM, Smulson ME, Hoffman BE, Guastella DB, Dawson VL, Dawson TM. Mandir AS, et al. Among authors: przedborski s. Proc Natl Acad Sci U S A. 1999 May 11;96(10):5774-9. doi: 10.1073/pnas.96.10.5774. Proc Natl Acad Sci U S A. 1999. PMID: 10318960 Free PMC article.

7

Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o'-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson's disease.

Pennathur S, Jackson-Lewis V, Przedborski S, Heinecke JW. Pennathur S, et al. Among authors: przedborski s. J Biol Chem. 1999 Dec 3;274(49):34621-8. doi: 10.1074/jbc.274.49.34621. J Biol Chem. 1999. PMID: 10574926 Free article.

8

Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease.

Przedborski S, Chen Q, Vila M, Giasson BI, Djaldatti R, Vukosavic S, Souza JM, Jackson-Lewis V, Lee VM, Ischiropoulos H. Przedborski S, et al. J Neurochem. 2001 Jan;76(2):637-40. doi: 10.1046/j.1471-4159.2001.00174.x. J Neurochem. 2001. PMID: 11208927 Free article.

9

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.

Vila M, Jackson-Lewis V, Vukosavic S, Djaldetti R, Liberatore G, Offen D, Korsmeyer SJ, Przedborski S. Vila M, et al. Among authors: przedborski s. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2837-42. doi: 10.1073/pnas.051633998. Epub 2001 Feb 13. Proc Natl Acad Sci U S A. 2001. PMID: 11226327 Free PMC article.

10

Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity.

Przedborski S, Kostic V, Jackson-Lewis V, Naini AB, Simonetti S, Fahn S, Carlson E, Epstein CJ, Cadet JL. Przedborski S, et al. J Neurosci. 1992 May;12(5):1658-67. doi: 10.1523/JNEUROSCI.12-05-01658.1992. J Neurosci. 1992. PMID: 1578260 Free PMC article.

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