Hackam AS - Search Results

1

The influence of huntingtin protein size on nuclear localization and cellular toxicity.

Hackam AS, Singaraja R, Wellington CL, Metzler M, McCutcheon K, Zhang T, Kalchman M, Hayden MR. Hackam AS, et al. J Cell Biol. 1998 Jun 1;141(5):1097-105. doi: 10.1083/jcb.141.5.1097. J Cell Biol. 1998. PMID: 9606203 Free PMC article.

2

Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.

Gervais FG, Singaraja R, Xanthoudakis S, Gutekunst CA, Leavitt BR, Metzler M, Hackam AS, Tam J, Vaillancourt JP, Houtzager V, Rasper DM, Roy S, Hayden MR, Nicholson DW. Gervais FG, et al. Among authors: hackam as. Nat Cell Biol. 2002 Feb;4(2):95-105. doi: 10.1038/ncb735. Nat Cell Biol. 2002. PMID: 11788820

3

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.

Wellington CL, Ellerby LM, Hackam AS, Margolis RL, Trifiro MA, Singaraja R, McCutcheon K, Salvesen GS, Propp SS, Bromm M, Rowland KJ, Zhang T, Rasper D, Roy S, Thornberry N, Pinsky L, Kakizuka A, Ross CA, Nicholson DW, Bredesen DE, Hayden MR. Wellington CL, et al. Among authors: hackam as. J Biol Chem. 1998 Apr 10;273(15):9158-67. doi: 10.1074/jbc.273.15.9158. J Biol Chem. 1998. PMID: 9535906 Free article.

4

In vitro evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease.

Hackam AS, Singaraja R, Zhang T, Gan L, Hayden MR. Hackam AS, et al. Hum Mol Genet. 1999 Jan;8(1):25-33. doi: 10.1093/hmg/8.1.25. Hum Mol Genet. 1999. PMID: 9887328

5

Evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease in cell culture and in transgenic mice expressing mutant huntingtin.

Hackam AS, Hodgson JG, Singaraja R, Zhang T, Gan L, Gutekunst CA, Hersch SM, Hayden MR. Hackam AS, et al. Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29;354(1386):1047-55. doi: 10.1098/rstb.1999.0457. Philos Trans R Soc Lond B Biol Sci. 1999. PMID: 10434304 Free PMC article. Review.

6

Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain.

Hackam AS, Yassa AS, Singaraja R, Metzler M, Gutekunst CA, Gan L, Warby S, Wellington CL, Vaillancourt J, Chen N, Gervais FG, Raymond L, Nicholson DW, Hayden MR. Hackam AS, et al. J Biol Chem. 2000 Dec 29;275(52):41299-308. doi: 10.1074/jbc.M008408200. J Biol Chem. 2000. PMID: 11007801 Free article.

7

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates.

Martindale D, Hackam A, Wieczorek A, Ellerby L, Wellington C, McCutcheon K, Singaraja R, Kazemi-Esfarjani P, Devon R, Kim SU, Bredesen DE, Tufaro F, Hayden MR. Martindale D, et al. Nat Genet. 1998 Feb;18(2):150-4. doi: 10.1038/ng0298-150. Nat Genet. 1998. PMID: 9462744

8

Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells.

Wellington CL, Singaraja R, Ellerby L, Savill J, Roy S, Leavitt B, Cattaneo E, Hackam A, Sharp A, Thornberry N, Nicholson DW, Bredesen DE, Hayden MR. Wellington CL, et al. J Biol Chem. 2000 Jun 30;275(26):19831-8. doi: 10.1074/jbc.M001475200. J Biol Chem. 2000. PMID: 10770929 Free article.

9

The fatal attraction of polyglutamine-containing proteins.

Hackam AS, Wellington CL, Hayden MR. Hackam AS, et al. Clin Genet. 1998 Apr;53(4):233-42. doi: 10.1111/j.1399-0004.1998.tb02687.x. Clin Genet. 1998. PMID: 9650759 Review. No abstract available.

10

Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.

Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, Hayden MR, Bredesen DE, Ellerby LM. Hermel E, et al. Among authors: hackam as. Cell Death Differ. 2004 Apr;11(4):424-38. doi: 10.1038/sj.cdd.4401358. Cell Death Differ. 2004. PMID: 14713958

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

72 results

Search Page

Filters