Hardman KD - Search Results

1

Design and synthesis of cyclic inhibitors of matrix metalloproteinases and TNF-alpha production.

Xue CB, He X, Roderick J, DeGrado WF, Cherney RJ, Hardman KD, Nelson DJ, Copeland RA, Jaffee BD, Decicco CP. Xue CB, et al. Among authors: hardman kd. J Med Chem. 1998 May 21;41(11):1745-8. doi: 10.1021/jm970849z. J Med Chem. 1998. PMID: 9599225 No abstract available.

2

Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships.

Duan JJ, Chen L, Wasserman ZR, Lu Z, Liu RQ, Covington MB, Qian M, Hardman KD, Magolda RL, Newton RC, Christ DD, Wexler RR, Decicco CP. Duan JJ, et al. Among authors: hardman kd. J Med Chem. 2002 Nov 7;45(23):4954-7. doi: 10.1021/jm0255670. J Med Chem. 2002. PMID: 12408705

3

Identification of a selectivity determinant for inhibition of tumor necrosis factor-alpha converting enzyme by comparative modeling.

Wasserman ZR, Duan JJ, Voss ME, Xue CB, Cherney RJ, Nelson DJ, Hardman KD, Decicco CP. Wasserman ZR, et al. Among authors: hardman kd. Chem Biol. 2003 Mar;10(3):215-23. doi: 10.1016/s1074-5521(03)00044-9. Chem Biol. 2003. PMID: 12670535

4

Design, synthesis, and evaluation of benzothiadiazepine hydroxamates as selective tumor necrosis factor-alpha converting enzyme inhibitors.

Cherney RJ, Duan JJ, Voss ME, Chen L, Wang L, Meyer DT, Wasserman ZR, Hardman KD, Liu RQ, Covington MB, Qian M, Mandlekar S, Christ DD, Trzaskos JM, Newton RC, Magolda RL, Wexler RR, Decicco CP. Cherney RJ, et al. Among authors: hardman kd. J Med Chem. 2003 May 8;46(10):1811-23. doi: 10.1021/jm020475w. J Med Chem. 2003. PMID: 12723945

5

Macrocyclic amino carboxylates as selective MMP-8 inhibitors.

Cherney RJ, Wang L, Meyer DT, Xue CB, Wasserman ZR, Hardman KD, Welch PK, Covington MB, Copeland RA, Arner EC, DeGrado WF, Decicco CP. Cherney RJ, et al. Among authors: hardman kd. J Med Chem. 1998 May 21;41(11):1749-51. doi: 10.1021/jm970850y. J Med Chem. 1998. PMID: 9599226 No abstract available.

6

Structure-based design and synthesis of a series of hydroxamic acids with a quaternary-hydroxy group in P1 as inhibitors of matrix metalloproteinases.

Jacobson IC, Reddy PG, Wasserman ZR, Hardman KD, Covington MB, Arner EC, Copeland RA, Decicco CP, Magolda RL. Jacobson IC, et al. Among authors: hardman kd. Bioorg Med Chem Lett. 1998 Apr 7;8(7):837-42. doi: 10.1016/s0960-894x(98)00125-5. Bioorg Med Chem Lett. 1998. PMID: 9871551

7

Macrocyclic hydroxamate inhibitors of matrix metalloproteinases and TNF-alpha production.

Cherney RJ, Wang L, Meyer DT, Xue CB, Arner EC, Copeland RA, Covington MB, Hardman KD, Wasserman ZR, Jaffee BD, Decicco CP. Cherney RJ, et al. Among authors: hardman kd. Bioorg Med Chem Lett. 1999 May 3;9(9):1279-84. doi: 10.1016/s0960-894x(99)00178-x. Bioorg Med Chem Lett. 1999. PMID: 10340614

8

P1, P2'-linked macrocyclic amine derivatives as matrix metalloproteinase inhibitors.

Duan JJ, Chen L, Xue CB, Wasserman ZR, Hardman KD, Covington MB, Copeland RR, Arner EC, Decicco CP. Duan JJ, et al. Among authors: hardman kd. Bioorg Med Chem Lett. 1999 May 17;9(10):1453-8. doi: 10.1016/s0960-894x(99)00215-2. Bioorg Med Chem Lett. 1999. PMID: 10360755

9

Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo.

Xue CB, Voss ME, Nelson DJ, Duan JJ, Cherney RJ, Jacobson IC, He X, Roderick J, Chen L, Corbett RL, Wang L, Meyer DT, Kennedy K, DeGradodagger WF, Hardman KD, Teleha CA, Jaffee BD, Liu RQ, Copeland RA, Covington MB, Christ DD, Trzaskos JM, Newton RC, Magolda RL, Wexler RR, Decicco CP. Xue CB, et al. Among authors: hardman kd. J Med Chem. 2001 Aug 2;44(16):2636-60. doi: 10.1021/jm010127e. J Med Chem. 2001. PMID: 11472217

10

Sultam hydroxamates as novel matrix metalloproteinase inhibitors.

Cherney RJ, Mo R, Meyer DT, Hardman KD, Liu RQ, Covington MB, Qian M, Wasserman ZR, Christ DD, Trzaskos JM, Newton RC, Decicco CP. Cherney RJ, et al. Among authors: hardman kd. J Med Chem. 2004 Jun 3;47(12):2981-3. doi: 10.1021/jm049833g. J Med Chem. 2004. PMID: 15163180

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