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Down-regulation of the pharmacokinetic-pharmacodynamic response to interleukin-12 during long-term administration to patients with renal cell carcinoma and evaluation of the mechanism of this "adaptive response" in mice.
Rakhit A, Yeon MM, Ferrante J, Fettner S, Nadeau R, Motzer R, Bukowski R, Carvajal DM, Wilkinson VL, Presky DH, Magram J, Gately MK. Rakhit A, et al. Clin Pharmacol Ther. 1999 Jun;65(6):615-29. doi: 10.1016/S0009-9236(99)90083-8. Clin Pharmacol Ther. 1999. PMID: 10391667 Clinical Trial.
Randomized multicenter phase II trial of subcutaneous recombinant human interleukin-12 versus interferon-alpha 2a for patients with advanced renal cell carcinoma.
Motzer RJ, Rakhit A, Thompson JA, Nemunaitis J, Murphy BA, Ellerhorst J, Schwartz LH, Berg WJ, Bukowski RM. Motzer RJ, et al. Among authors: rakhit a. J Interferon Cytokine Res. 2001 Apr;21(4):257-63. doi: 10.1089/107999001750169934. J Interferon Cytokine Res. 2001. PMID: 11359657 Clinical Trial.
Phase 1b dose escalation study of erlotinib in combination with infusional 5-Fluorouracil, leucovorin, and oxaliplatin in patients with advanced solid tumors.
Hanauske AR, Cassidy J, Sastre J, Bolling C, Jones RJ, Rakhit A, Fettner S, Brennscheidt U, Feyereislova A, Díaz-Rubio E. Hanauske AR, et al. Among authors: rakhit a. Clin Cancer Res. 2007 Jan 15;13(2 Pt 1):523-31. doi: 10.1158/1078-0432.CCR-06-1627. Clin Cancer Res. 2007. PMID: 17255274 Clinical Trial.
67 results