Nuccetelli M - Search Results

1

Proton release upon glutathione binding to glutathione transferase P1-1: kinetic analysis of a multistep glutathione binding process.

Caccuri AM, Lo Bello M, Nuccetelli M, Nicotra M, Rossi P, Antonini G, Federici G, Ricci G. Caccuri AM, et al. Among authors: nuccetelli m. Biochemistry. 1998 Mar 3;37(9):3028-34. doi: 10.1021/bi971903g. Biochemistry. 1998. PMID: 9485455

2

Site-directed mutagenesis of human glutathione transferase P1-1. Mutation of Cys-47 induces a positive cooperativity in glutathione transferase P1-1.

Ricci G, Lo Bello M, Caccurri AM, Pastore A, Nuccetelli M, Parker MW, Federici G. Ricci G, et al. Among authors: nuccetelli m. J Biol Chem. 1995 Jan 20;270(3):1243-8. doi: 10.1074/jbc.270.3.1243. J Biol Chem. 1995. PMID: 7836386 Free article.

3

Structural flexibility modulates the activity of human glutathione transferase P1-1. Influence of a poor co-substrate on dynamics and kinetics of human glutathione transferase.

Caccuri AM, Ascenzi P, Antonini G, Parker MW, Oakley AJ, Chiessi E, Nuccetelli M, Battistoni A, Bellizia A, Ricci G. Caccuri AM, et al. Among authors: nuccetelli m. J Biol Chem. 1996 Jul 5;271(27):16193-8. doi: 10.1074/jbc.271.27.16193. J Biol Chem. 1996. PMID: 8663073 Free article.

4

Multifunctional role of Tyr 108 in the catalytic mechanism of human glutathione transferase P1-1. Crystallographic and kinetic studies on the Y108F mutant enzyme.

Lo Bello M, Oakley AJ, Battistoni A, Mazzetti AP, Nuccetelli M, Mazzarese G, Rossjohn J, Parker MW, Ricci G. Lo Bello M, et al. Among authors: nuccetelli m. Biochemistry. 1997 May 20;36(20):6207-17. doi: 10.1021/bi962813z. Biochemistry. 1997. PMID: 9166793

5

Shifting substrate specificity of human glutathione transferase (from class Pi to class alpha) by a single point mutation.

Nuccetelli M, Mazzetti AP, Rossjohn J, Parker MW, Board P, Caccuri AM, Federici G, Ricci G, Lo Bello M. Nuccetelli M, et al. Biochem Biophys Res Commun. 1998 Nov 9;252(1):184-9. doi: 10.1006/bbrc.1998.9575. Biochem Biophys Res Commun. 1998. PMID: 9813167

6

Mutations of Gly to Ala in human glutathione transferase P1-1 affect helix 2 (G-site) and induce positive cooperativity in the binding of glutathione.

Lo Bello M, Nuccetelli M, Chiessi E, Lahm A, Mazzetti AP, Battistoni A, Caccuri AM, Oakley AJ, Parker MW, Tramontano A, Federici G, Ricci G. Lo Bello M, et al. Among authors: nuccetelli m. J Mol Biol. 1998 Dec 18;284(5):1717-25. doi: 10.1006/jmbi.1998.2270. J Mol Biol. 1998. PMID: 9878382

7

Temperature adaptation of glutathione S-transferase P1-1. A case for homotropic regulation of substrate binding.

Caccuri AM, Antonini G, Ascenzi P, Nicotra M, Nuccetelli M, Mazzetti AP, Federici G, Lo Bello M, Ricci G. Caccuri AM, et al. Among authors: nuccetelli m. J Biol Chem. 1999 Jul 2;274(27):19276-80. doi: 10.1074/jbc.274.27.19276. J Biol Chem. 1999. PMID: 10383436 Free article.

8

The ligandin (non-substrate) binding site of human Pi class glutathione transferase is located in the electrophile binding site (H-site).

Oakley AJ, Lo Bello M, Nuccetelli M, Mazzetti AP, Parker MW. Oakley AJ, et al. Among authors: nuccetelli m. J Mol Biol. 1999 Aug 27;291(4):913-26. doi: 10.1006/jmbi.1999.3029. J Mol Biol. 1999. PMID: 10452896

9

Lack of glutathione conjugation to adriamycin in human breast cancer MCF-7/DOX cells. Inhibition of glutathione S-transferase p1-1 by glutathione conjugates from anthracyclines.

Gaudiano G, Koch TH, Lo Bello M, Nuccetelli M, Ravagnan G, Serafino A, Sinibaldi-Vallebona P. Gaudiano G, et al. Among authors: nuccetelli m. Biochem Pharmacol. 2000 Dec 15;60(12):1915-23. doi: 10.1016/s0006-2952(00)00521-9. Biochem Pharmacol. 2000. PMID: 11108808

10

Valine 10 may act as a driver for product release from the active site of human glutathione transferase P1-1.

Micaloni C, Mazzetti AP, Nuccetelli M, Rossjohn J, McKinstry WJ, Antonini G, Caccuri AM, Oakley AJ, Federici G, Ricci G, Parker MW, Lo Bello M. Micaloni C, et al. Among authors: nuccetelli m. Biochemistry. 2000 Dec 26;39(51):15961-70. doi: 10.1021/bi0007122. Biochemistry. 2000. PMID: 11123923

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