Lacal JC - Search Results

1

Choline kinase inhibitors as a novel approach for antiproliferative drug design.

Hernández-Alcoceba R, Saniger L, Campos J, Núñez MC, Khaless F, Gallo MA, Espinosa A, Lacal JC. Hernández-Alcoceba R, et al. Among authors: lacal jc. Oncogene. 1997 Nov 6;15(19):2289-301. doi: 10.1038/sj.onc.1201414. Oncogene. 1997. PMID: 9393874

2

Inhibition of choline kinase as a specific cytotoxic strategy in oncogene-transformed cells.

Rodríguez-González A, Ramírez de Molina A, Fernández F, Ramos MA, del Carmen Núñez M, Campos J, Lacal JC. Rodríguez-González A, et al. Among authors: lacal jc. Oncogene. 2003 Dec 4;22(55):8803-12. doi: 10.1038/sj.onc.1207062. Oncogene. 2003. PMID: 14654777

3

Preclinical characterization of RSM-932A, a novel anticancer drug targeting the human choline kinase alpha, an enzyme involved in increased lipid metabolism of cancer cells.

Lacal JC, Campos JM. Lacal JC, et al. Mol Cancer Ther. 2015 Jan;14(1):31-9. doi: 10.1158/1535-7163.MCT-14-0531. Epub 2014 Dec 8. Mol Cancer Ther. 2015. PMID: 25487918

4

In vivo antitumor activity of choline kinase inhibitors: a novel target for anticancer drug discovery.

Hernández-Alcoceba R, Fernández F, Lacal JC. Hernández-Alcoceba R, et al. Among authors: lacal jc. Cancer Res. 1999 Jul 1;59(13):3112-8. Cancer Res. 1999. PMID: 10397253

5

Modulation of phospholipase D by hexadecylphosphorylcholine: a putative novel mechanism for its antitumoral activity.

Lucas L, Hernández-Alcoceba R, Penalva V, Lacal JC. Lucas L, et al. Among authors: lacal jc. Oncogene. 2001 Mar 1;20(9):1110-7. doi: 10.1038/sj.onc.1204216. Oncogene. 2001. PMID: 11314048

6

QSAR-derived choline kinase inhibitors: how rational can antiproliferative drug design be?

Campos J, Núñez MC, Conejo-García A, Sánchez-Martín RM, Hernández-Alcoceba R, Rodríguez-González A, Lacal JC, Gallo MA, Espinosa A. Campos J, et al. Among authors: lacal jc. Curr Med Chem. 2003 Jul;10(13):1095-112. doi: 10.2174/0929867033457539. Curr Med Chem. 2003. PMID: 12678804 Review.

7

Choline kinase inhibitory effect and antiproliferative activity of new 1,1',1"-(benzene-1,3,5-triylmethylene)tris[4-[(disubstituted)amino]pyridinium] tribromides.

Conejo-García A, Campos J, Sánchez RM, Rodríguez-González A, Lacal JC, Gallo MA, Espinosa A. Conejo-García A, et al. Among authors: lacal jc. Eur J Med Chem. 2003 Jan;38(1):109-16. doi: 10.1016/s0223-5234(02)00004-1. Eur J Med Chem. 2003. PMID: 12593921

8

Symmetrical bis-quinolinium compounds: new human choline kinase inhibitors with antiproliferative activity against the HT-29 cell line.

Sánchez-Martín R, Campos JM, Conejo-García A, Cruz-López O, Báñez-Coronel M, Rodríguez-González A, Gallo MA, Lacal JC, Espinosa A. Sánchez-Martín R, et al. Among authors: lacal jc. J Med Chem. 2005 May 5;48(9):3354-63. doi: 10.1021/jm049061o. J Med Chem. 2005. PMID: 15857141

9

Influence of the linker in bispyridium compounds on the inhibition of human choline kinase.

Conejo-García A, Báñez-Coronel M, Sánchez-Martín RM, Rodríguez-González A, Ramos A, Ramírez de Molina A, Espinosa A, Gallo MA, Campos JM, Lacal JC. Conejo-García A, et al. Among authors: lacal jc. J Med Chem. 2004 Oct 21;47(22):5433-40. doi: 10.1021/jm0496537. J Med Chem. 2004. PMID: 15481981

10

Choline Kinase: An Unexpected Journey for a Precision Medicine Strategy in Human Diseases.

Lacal JC, Zimmerman T, Campos JM. Lacal JC, et al. Pharmaceutics. 2021 May 25;13(6):788. doi: 10.3390/pharmaceutics13060788. Pharmaceutics. 2021. PMID: 34070409 Free PMC article. Review.

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